Creatine

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creatine

[′krē·ə‚tēn]
(biochemistry)
C4H9O2N3α-Methylguanidine-acetic acid; a compound present in vertebrate muscle tissue, principally as phosphocreatine.

Creatine

 

N-methylguanidoacetic acid. Molecular weight, 131.14; melting point, 315°C (with dissociation):

Creatine is soluble in hot water, slightly soluble in alcohol, and insoluble in ether. The interaction of mineral acids and creatine produces the lactam creatinine. This reaction is the basis of one of the methods used to determine creatine content. Creatine dissociates into urea and methylglycine in an alkaline medium.

Creatine was discovered in 1835 by the French scientist M. Chevreul in extracts from skeletal muscles. It is found in the muscle tissue of all vertebrates (approximately 0.5 percent of the muscle weight) in the form of the unstable creatinephosphoric acid, which takes part in supplying the energy required for muscle contraction. Smaller quantities are present in nerve tissue, blood, liver, and kidneys. Creatine biosynthesis in an organism is achieved in the kidneys from the amino acids glycine and arginine, forming glycocyamine. The glycocyamine undergoes subsequent methylation in the liver in the presence of the amino acid methionine to yield creatine.

N. P. MESHKOVA

References in periodicals archive ?
As table 3 shows no significant difference was found in serum level of creatin kinase between normal intrauterine and ruptured ectopic pregnancies(p=0.
Children from across the city spent weeks making costumes in preparation for the event, with schools, dance groups and commu nity centres all involved in creatin the colourful spectacle.
A algunos pacientes con sospecha clinica de miocarditis se le realizaron las siguientes pruebas diagnosticas, previo consentimiento informado, para identificar la miocarditis: ecocardiograma, creatin fosfoquinasa fraccion MB (CPK MB) mediante la tecnica de inmunoinhibicion usando un kit comercial (Hitachi 911, Roche, Manheim, Germany).
Un grupo de 28 pacientes en edad pediatrica fueron diagnosticados como distrofia muscular Duchenne/Becker utilizando pruebas enzimaticas como Creatin Posfoquinasa (CPK), aldolasa y deshidrogenasa lactica (DHL) y biopsia muscular (Figura 6).
Un grupo de 28 pacientes en edad pediatrica fueron diagnosticados como distrofia muscular Duchenne/Becker utilizando pruebas enzimaticas como Creatin Fosfoquinasa (CPK), aldolasa y deshidrogenasa lactica (DHL) y biopsia muscular (Figura 6).
Indeed, we have to consider that serum creatinine is an end-product of increased creatin phosphate formation by aerobic metabolism.
With Rooibos extracts and creatin, the Lifetex Resist shampoo provides an instant boost to hair.
En relacion a los parametros bioquimicos evaluados, no hubo diferencias significativas, en los valores hematologicos, de urea y creatin ina, lo cual indica que estos compuestos aparentemente no influyeron en la funcion renal ni en la medula osea.
1988), indicaron que la funcion espermatica defectuosa esta asociada con una actividad elevada de ciertas enzimas claves, incluyendo la creatin kinasa (CK), lactato deshidrogenasa (LDH) y glucosa-6-fosfato deshidrogenasa (G-6-PDH); se sugirio que los errores de espermiogenesis pueden conllevar a una elevacion de la CK durante el estres oxidativo, ya que el dano peroxidativo esta relacionado con la actividad de esta enzima (Huszar & Vigue, 1993; Aitken & Fisher, 1994).
15) The justification for creatin g transgenic beings, though, is that such beings can illuminate particular aspects of biology in ways impossible (or at least supremely difficult) through non-transgenic research.