Phosphocreatine

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phosphocreatine

[¦fäs·fō′krē·ə‚tēn]
(biochemistry)
C4H10N3O5P Creatine phosphate, a phosphoric acid derivative of creatine which contains an energy-rich phosphate bond; it is present in muscle and other tissues, and during the anaerobic phase of muscular contraction it hydrolyzes to creatine and phosphate and makes energy available. Abbreviated PC.

Phosphocreatine

 

(creatine phosphate, creatine phosphoric acid), a product of creatine phosphorylation; an energy-rich compound.

Phosphocreatine was first discovered in 1927 in fresh specimens of muscle tissue. It can be prepared by treating creatine with POCI3 in an alkaline medium. One of the energy sources for muscle contraction is the readily reversible decomposition of phosphocreatine, catalyzed by the enzyme creatinase: phosphocreatine + ADP ⇄ creatine + ATP. A decrease in the ATP content in the tissues leads to the decomposition of phosphocreatine; an increase in ATP content leads to its synthesis. Thus, phosphocreatine forms a reserve of energy-rich phosphate, both the phosphate and stored energy of which can be used in the formation of ATP. In tissues, phosphocreatine undergoes gradual spontaneous decomposition to yield inorganic phosphate and creatinine, which is eliminated with the urine. Arginine phosphate replaces phosphocreatine in many invertebrates (for example, insects).

N. P. MESHKOVA

References in periodicals archive ?
Simultaneous determination of myocardial nucleotides, nucleosides, purine bases and creatine phosphate by ion-pair high-performance liquid chromatography.
creatine phosphate into heart mitochondria: a leak in the creatine
Diffusion coefficients of ATP and creatine phosphate in isolated muscle: pulsed gradient31P NMR of small biological samples.
The enzyme responsible for catalyzing the transfer of high-energy phosphate from creatine phosphate to ATP is creatine kinase (CK).
CK plays a major role in fast muscle contraction by supplying creatine phosphate, which is used for ATP production, especially under anaerobic conditions.
The [K.sub.m] values of r-hCK-MB for creatine phosphate (CP) and ADP were determined under conditions described in the Japanese method with CP and ADP at concentrations of 0.1-100 and 0.01-10 mmol/L, respectively.
During muscle contraction, creatine and creatine phosphate are spontaneously converted to creatinine.
No cross-reactivity (within [+ or -] 1.0%) was observed with various substances, including sarcosine, creatinine, creatine phosphate, guanidinoacetic acid, guanidinosuccinic acid, [gamma]-guanidinobutyric acid, [beta]-guanidinopropionic acid, methylguanidine, arginine, arginosuccinic acid, alanine, aspartic acid, ornithine, citrulline, proline, cysteine, tryptophan, methionine, glutathione (reduced and oxidized forms), and ascorbic acid, respectively, each at a concentration of 100 [micro]mol/L.
Determination of Optimum Reaction Conditions Gabor Szasz, l Wolfgang Gruber, 2 and Erich Bernt 2 To establish optimum conditions for creatine kinase (EC 2.7.3.2) activity measurement with the creatine phosphate [right arrow] creatine reaction, we re-examined all kinetic factors relevant to an optimal and standardized enzyme assay at 30 and 25 [degrees]C.

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