However, if the blood pressure is very low, whether due to over correction with medication, shock, or adrenal insufficiency, this can raise creatinine
. (2) In practice, a patient with a creatinine
of 8.0 would seem to be headed straight for dialysis.
Using non-probability convenience sampling, apparently normal healthy male and female volunteers were enrolled.12 Those with slightly raised serum creatinine
and those with blood sugar levels within pre-diabetes range on previous reports were excluded, and so were those who gave history of antihypertensive medication or use of steroid.
Clinical evaluation of serum Cystatin C and creatinine
in patients with chronic kidney disease: a meta-analysis (2013) (12)
A 24-h urine collection revealed a urinary creatinine
excretion of 1160 mg.
Although participants 10 and 18 were not clinically diagnosed with CKD, these participants were excluded because the creatinine
concentrations were not appropriate for the non-CKD group (mean concentrations, 1.8 [+ or -] 0.2 mg/dL and 2.0 [+ or -] 0.08 mg/dL, respectively).
The relationship between serum creatinine
is inversely proportional to eGFR, which starts to drop before creatinine
significantly rises in the early stages of injury, proving eGFR calculations to be more sensitive than creatinine
Despite medical developments, acute kidney injury (AKI) remains an important clinical problem with high morbidity and mortality.1 Today, the plasma creatinine
level is used in AKI diagnosis; however, it is a non-specific and insensitive marker since these levels vary in other conditions causing extrarenal azotemia and do not increase until 50% of kidney functions are lost.
Recruited patients were referred either to nephrology or ICU clinics at 3 months when serum creatinine
and cystatin C were measured.
Six samples of human urine were analyzed for creatinine
, uric acid, and hypoxanthine as an application of the method.
has been widely used as a marker of GFR but it is not sensitive enough to detect decreased renal function at an early stage of disease without albuminuria3.
A blood test of kidney function known as cystatin C has been shown to be an alternative, better marker of creatinine
, compared with GFR, and is supported by the Kidney Disease: Improving Global Outcomes CKD work group's 2012 clinical practice guidelines for the evaluation and management of CKD.
Serum urea was estimated by Berthelot's method while creatinine
was estimated by alkaline Jaffe's Picrate method. These biochemical parameters were determined by using a fully automated clinical chemistry analyzer.