The most important pathway for absorption of CSF is via lymphatics in the olfactory tract,
cribiform plate and cervical lymphatic vessels(1).
(28) The portal of entry for humans appears to be the nasal mucosa with subsequent invasion of the olfactory nerve plexus and rapid travel ( (24) hours) of the amoebae up the olfactory nerves, through the
cribiform plate and into olfactory bulb and spread to other areas of the CNS.
Those thin, spaghettilike nerves run from the nose through an opening in a skull segment called the
cribiform plate.
The diagnosis was a misplaced nasogastric tube forced through the
cribiform plate.
The most common features identified in the series were poor differentiation (n = 12), pushing infiltrative margin (n = 11), Crohn-like reaction (n = 10), and
cribiform architecture (n = 8).
The ductal papillar carcinoma with infiltration and the
cribiform carcinoma with areas of adenoid cystic pattern.
Postradiation examination revealed a 6-mm mass at the posterior aspect of the
cribiform plate.
Drainage also occurs through the arachnoid villi in the sub-arachnoid space, flowing via blood and lymph into the lymphatics of the cranial nerves, the spinal nerves, inner ear and the
cribiform plate of the ethmoid bone (forms the roof of the nasal cavity) (1).
Remarkably, there were mild, widely scattered infiltrations of neutrophils in the remaining olfactory nerve bundles penetrating the bony
cribiform plate that separates the nasal cavity and OB of the brain (Figure 8D).
5.) In malignant cells there usually is only one layer of cuboidal cells, and a characteristic
cribiform pattern may develop.
Our experience with this case suggests a mechanism of injury to the
cribiform plate during septoplasty that has not been described previously.
Histologic diagnosis of the mammary tumors revealed that they were adenocarcinomas, grossly nodular and encapsulated, with areas of
cribiform or papillary patterns (Figure 7C, D).