The most important pathway for absorption of CSF is via lymphatics in the olfactory tract, cribiform
plate and cervical lymphatic vessels(1).
(28) The portal of entry for humans appears to be the nasal mucosa with subsequent invasion of the olfactory nerve plexus and rapid travel ( (24) hours) of the amoebae up the olfactory nerves, through the cribiform
plate and into olfactory bulb and spread to other areas of the CNS.
Those thin, spaghettilike nerves run from the nose through an opening in a skull segment called the cribiform
The diagnosis was a misplaced nasogastric tube forced through the cribiform
The most common features identified in the series were poor differentiation (n = 12), pushing infiltrative margin (n = 11), Crohn-like reaction (n = 10), and cribiform
architecture (n = 8).
The ductal papillar carcinoma with infiltration and the cribiform
carcinoma with areas of adenoid cystic pattern.
Postradiation examination revealed a 6-mm mass at the posterior aspect of the cribiform
Drainage also occurs through the arachnoid villi in the sub-arachnoid space, flowing via blood and lymph into the lymphatics of the cranial nerves, the spinal nerves, inner ear and the cribiform
plate of the ethmoid bone (forms the roof of the nasal cavity) (1).
Remarkably, there were mild, widely scattered infiltrations of neutrophils in the remaining olfactory nerve bundles penetrating the bony cribiform
plate that separates the nasal cavity and OB of the brain (Figure 8D).
5.) In malignant cells there usually is only one layer of cuboidal cells, and a characteristic cribiform
pattern may develop.
Our experience with this case suggests a mechanism of injury to the cribiform
plate during septoplasty that has not been described previously.
Histologic diagnosis of the mammary tumors revealed that they were adenocarcinomas, grossly nodular and encapsulated, with areas of cribiform
or papillary patterns (Figure 7C, D).