Antigenic relationships between flaviviruses as determined by cross-neutralization
tests with polyclonal antisera.
This and other studies have underscored a widespread pattern of cross-neutralization
of antivenoms against heterologous Bothrops sp.
In spite of the antigenic differences between VSV serotypes, variable levels of cross-neutralization
are observed among VSIV-1, 2 e 3 (PAUSZEK et al., 2011).
These differences may contribute to the distinct pattern of MAb binding and to differences in cross-neutralization
between BoHV-1 and BoHV-5 (17).
Brunet, "Efficacy of a bivalent inactivated non-adjuvanted feline calicivirus vaccine: relation between in vitro cross-neutralization
and heterologous protection in vivo," Vaccine, vol.
Finally, the predicted recognition of W437 by e20 and e137 does not limit their cross-recognition and cross-neutralization
profile of different genotypes/isolates as conversely observed by Duan et al.
of influenza A viruses mediated by a single antibody loop." Nature published online 16 September 2012.
This report (("A dual-strain feline calicivirus vaccine stimulates broader cross-neutralization
antibodies than a single-strain vaccine and lessens clinical signs in vaccinated cats when challenged with a homologous feline calicivirus strain associated with virulent systemic disease" in Journal of Feline Medicne and Surgery, 2010)) describes the ability of a vaccine containing two different strains of FCV to induce protection in vaccinated animals against many strains of the virus.
Several groups have recently revealed that chimeric VLP in which the cross-neutralization
epitope of L2 inserted induce cross-neutralizing antibodies more effectively (27,28).
Weiss told SCIENCE NEWS that this cross-neutralization
offers hope that broad-spectrum drugs may be effective against the changeable HIV-1 virus, which, like the influenza virus, is notorious for its rapid mutation rate (SN: 6/28/86, p.410).
However, we have previously observed no evidence of PeV-A3 cross-neutralization
by polyclonal and monoclonal antibodies elicited against PeV-A1 to 5 (14,15).
Studies shown that no antibody against ONN was produced eliminating the possibility of 2-way cross-neutralization
test between CHIK and ONN viruses (11,12).