cross-tolerance


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cross-tolerance

[¦krȯs ′täl·ə·rəns]
(medicine)
Tolerance or resistance to the action of a drug brought about by continued use of another drug of similar pharmacologic action.
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References in periodicals archive ?
Prior experience with wheel running produces cross-tolerance to the rewarding effect of morphine.
Interestingly, p65-Ser536 phosphorylation is resumed and low-dose TNF-induced tolerance is reversed by glycogen synthesis kinase (GSK) 3 inhibition using SB6763 [4], an effect also described within TNF-induced cross-tolerance towards LPS [6].
Cross-sensitization and cross-tolerance between exogenous cannabinoid antinociception and endocannabinoid-mediated stress-induced analgesia.
KEY WORDS: Alcohol and tobacco; alcoholism; cigarette smoking; nicotine dependence; brain; neuronal nicotinic acetylcholine receptors; cross-tolerance; alcohol and other drug (AOD) sensitivity; genetic factors; genetic polymorphism; laboratory mice; laboratory rat; neurotoxicity
For the experimental conditions studied here, drying rate was always observed to affect viability, however, no interaction parameters were implemented to model the cross-tolerance of drying rate and moisture content.
Incomplete cross-tolerance from one opioid to another can result in improved pain relief at lower-than-equianalgesic dosing of an alternate opioid (McCaffery & Pasero, 1999).
Acclimation to Stresses and Cross-Tolerance To Stresses
Crosses between two wild oat biotypes (UM1 and UM33) differing in their herbicide cross-tolerance patterns indicated that the biotypes had different dominant alleles of the same gene (22).
This drug-induced biotransformation of itself and other drugs is another source of tolerance and cross-tolerance. Various anesthetics, ethanol, and the sedative-hypnotic drugs are metabolized by and induce the microsomal enzymes to produce multidirectional cross-tolerance.
In the case of cross-tolerance of TLRLs, after sequential activations of different TLRLs, reduced inflammatory responses are often observed upon the second TLR stimulation by attenuated activation of immune cells involving macrophages.