The results suggest that alveoli intruded by inhaled cryptococci
were expanded due to extensive yeast proliferation, and that C.
Transbronchial biopsy showed lung parenchyma diffusely infiltrated by cryptococci
Several reasons for this anomaly seem possible: some of these specimens could have contained cryptococci
that required >48 hours to demonstrate growth; recent experience in the laboratory has shown that an additional 12% of cryptococcal isolates will be found only when cultures are incubated for 7 days.
These events raise the possibility of direct percutaneous inoculation or the possibility of translocation of the cryptococci
from the GI site into the blood stream.
Clearance of cryptococci
from cerebrospinal fluid (CSF), as measured by a new primary end point--the decline in CSF cryptococcal colony forming units (CFU) over time--occurred significantly more quickly in the amphotericin B/flucytosine patients (decrease of 0.54 log CFU/day), than in the amphotericin B-only patients (decrease of 0.31 log CFU/day), the amphotericin B plus fluconazole patients (decrease of 0.39 log CFU/day), or the triple therapy patients (decrease of 0.38 log CFU/day), the investigators found (Lancet 363:1764-67, 2004).
To ensure that I caught all the possible variants (e.g., cryptococci
, cryptococcal, etc.), I used the "*" character to truncate the search term.
Based on the distribution of specific antigenic determinants on the polysaccharide capsule, pathogenic cryptococci
have been divided into capsular serotypes B and C (both C.
False-positive results can occur, however, if an inexperienced reader mistakes lymphocytes for cryptococci
. The India ink test is simple to perform, rapid, and, when positive, is diagnostic for cryptococcal meningitis.