M2 PHARMA-March 4, 2019-Innovus Pharma's Diabasens Product Approved in Canada Indicated to Relieve Cutaneous Pain Associated with Diabetic Neuropathy
(OTCQB Venture Market: INNV) has received approval from Health Canada to market its product Diabasens as a Natural Health Product, for the indication to relieve cutaneous pain associated with diabetic neuropathy, the company said.
In ovariectomy-induced rodent models of osteoporosis, cutaneous pain hypersensitivity develops within 4-10 weeks and is dependent on estrogen depletion; estrogen replacement therapy prevents both bone loss and cutaneous pain in the early stages of the pathology [5-9].
Although the efficacy of acute morphine on cutaneous pain was weak, pregabalin was highly effective.
O'Brien cited as one example a Harvard University study of 28 patients exhibiting migraine with the associated cutaneous pain
and tenderness known as allodynia.
(22% respondents) was the main complaint followed by limb deformity (15%) and lack of knowledge (18%).
Gradual increase in cutaneous pain
threshold was found in healthy subjects and patients with atopic eczema during repeated hypnotic sessions with specific suggestions.
Contribution of neurokinin 1 receptors in the cutaneous orofacial cutaneous pain
. Naunyn-Schmiede-bergs Archiv.
Somatic nociceptors, found in blood vessels, ligaments, and bones, have a low concentration of nerve endings, yielding dull, more diffuse pain that typically lasts longer than cutaneous pain