cyclamate


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cyclamate

(sī'kləmāt', –mət), any member of a group of salts of cyclamic acid (cyclohexanesulfamic acid). The sodium and calcium salts were commonly used as artificial sweetenerssweetener, artificial,
substance used as a low-calorie sugar substitute. Saccharin, cyclamates, and aspartame have been the most commonly used artificial sweeteners. Saccharin, a coal-tar derivative three hundred times as sweet as sugar, was discovered in 1879.
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 until 1969, when their use was banned by the U.S. Food and Drug Administration after reports that ingestion of large quantities of cyclamates appeared to cause cancer in some animals. There is no evidence that cyclamates are associated with cancer in humans.

cyclamate

[′sī·klə‚māt]
(organic chemistry)
The calcium or sodium salt of cyclohexylsulfamate, an artificial sweetener.
References in periodicals archive ?
Results for the quantitative parameters fetal weight, placental weight, umbilical-cord length for control rat fetuses and those treated with sodium cyclamate are shown in Table I.
[7] FDA Food and Drugs Administration, "Cyclamate (Cyclamic Acid, Calcium Cyclamate and Sodium Cyclamate) Commissioner's Decision," http://www.fda.gov/downloads/Food/IngredientsPackagingLabeling/FoodAdditivesIngredients/UCM404-344.pdf.
Artificial Sweeteners are further classified into Alitame, Sucralose, Aspartame, Neotame, Cyclamate, Acesulfame Potassium and Saccharin.
Objective: To observe the effects of sodium cyclamate on islets of langerhans in rats pancreas.
In value terms of the overall intense sweetener market, the big movers from 2013 to 2017 are stevia, acesulfame-K and sucralose, while aspartame and cyclamate are predicted to show the greatest decline.
The committee also decided to ban sodium cyclamate, a sweetening pharmaceutical item, from all drug markets in the UAE due to its dangerous side effects on liver and cancer causing effects.
Artificial sweeteners Sucralose (Splenda[R], SucraPlus[TM]), acesulfame, saccharin, cyclamate, etc.
"A few additives once assumed to be safe, such as cyclamate salts and sulfites, are now banned or no longer considered GRAS."
Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3.
The disclosing tablets of bacterial plaque used were composed of alkaline fuchsin 2%, sodium saccharin, lactose, sodium cyclamate and excipients, whose function is to stain the bacterial plaque on the teeth apparently clean, with a contrasting color (bright red), facilitating to localize the bacterial plaque on the teeth surface.
Cyclamate has a major metabolite, cyclohexylamine, which causes testicular atrophy and at high doses, it has unwanted cardiovascular effects (Bopp and Price, 2001).
There are two types of high-intensity sweeteners: artificial sweeteners--such as alitame, cyclamate, aspartame, neotame, potassium acesulfame (Ace K) and saccharin--and natural high-intensity sweeteners extracted from various plant sources--such as stevia and luo han guo (monk fruit).