cyclase


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Related to cyclase: Guanylate cyclase

cyclase

[′sī‚klās]
(biochemistry)
An enzyme that catalyzes cyclization of a compound.
References in periodicals archive ?
'Since Cyclerion launched as an independent public company in April, we have made excellent progress advancing our five programs targeting the soluble guanylate cyclase pathway.
In June 2018, we announced that we had entered into a research collaboration agreement with Ironwood Pharmaceuticals, Inc., a commercial biotechnology company, focused on combining Ironwood's expertise in soluble guanylate cyclase (sGC) and our proprietary nitric oxide (NO)-donating research platform to generate novel compounds in order to identify potential new therapeutics for the treatment of certain ophthalmic conditions.
An initial insult results in an increase in nitric oxide synthase and nitric oxide which, viaguanylyl cyclase, increases cGMP, and down-stream signaling, ultimately resulting in dephosphorylation of myosin and vasodilation [1].
Alcohol dehydrogenase, NAD, ADP-ribosyl cyclase, nicotinamide, resazurin, diaphorase, bovine serum albumin (BSA), 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT), bicine, riboflavin 5'-mono-phosphate (FMN), phenazine ethosulfate (PES), ethylenediaminetetraacetic acid (EDTA)-Na, alcohol dehydrogenase (ADH), and 8-Br-cADPR were purchased from Sigma-Aldrich (St.
Specific inhibitors and antagonists were used as follows: [beta]AR antagonists, [10.sup.-7] M CG[beta]20712A for [beta]1AR, [10.sup.-7] M ICI-118,551 for [beta]2AR, and [10.sup.-7] M SR59230A for [beta]3AR; adenylyl cyclase inhibitor, [10.sup.-7] M SQ22536; PKA inhibitor, [10.sup.-7] M H89; guanylyl cyclase inhibitor, [10.sup.-7] M ODQ; and PGK inhibitor, [10.sup.-7] M K75823.
VIP inhibits HC proliferation by eliciting signal transduction through one of its G protein-coupled receptors (GPCR), designated vasoactive pituitary adenylate cyclase activating peptide receptor 1 (VPAC1).
For example, in pulmonary endothelium, cAMP produced by plasma membrane-localized adenylyl cyclase is endothelial barrier protective; whereas, cAMP produced by both endogenous and heterologously-expressed AC is barrier disruptive [6,7].
It has been reported that PACAP activates not only adenylate cyclase (AC), which eventually activates the PKA signaling pathway, but also PLC, which leads to an increase in intracellular calcium signaling.
Shannon Boye, assistant professor of ophthalmology at the U of Florida, to fund her LCA-1 research focused on the gene mutation called guanylate cyclase (GUCY2D).
Fremont, CA, May 29, 2014 --(PR.com)-- AnaSpec is pleased to announce the release of the first commercially available 96-well format, fluorimetric assay for measuring Glutaminyl Cyclase (QC) activity - the SensoLyte[R] Green Glutaminyl Cyclase Activity Assay Kit.
Merck also announced a worldwide clinical development collaboration with Bayer to market and develop its portfolio of soluble guanylate cyclase (sGC) modulators, including Bayer's Adempas (riociguat).