cyclase


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Related to cyclase: Guanylate cyclase

cyclase

[′sī‚klās]
(biochemistry)
An enzyme that catalyzes cyclization of a compound.
References in periodicals archive ?
Oral sGC stimulator Vericiguat in patients with worsening chronic heart failure and reduced ejection fraction - The SOluble guanylate Cyclase stimulatoR in heArT failurE patientS with REDUCED EF (SOCRATES-REDUCED) Study Mihai Gheorghiade (Chicago, U.
During acquisition, 50 [micro]M Forskolin (adenylate cyclase activator) is added at 5 minutes of time and 10 [micro]M Rolipram+ 500 [micro]M IBMX (phosphodiesterase inhibitors) were added at time point of 15 minutes.
Glutaminyl cyclase (QC), an enzyme found in animals and plants, catalyzes the cyclization of N-terminal Glutamine, and to a lesser extent Glutamate, to pyroglutamate (1).
Konrad Glund, CEO of Probiodrug, commented, "There is increasing appreciation for the role of pGlu Abeta and glutaminyl cyclase (QC) in the development and progression of Alzheimer's disease.
Topics include specialization in Bordetella as deduced from comparative genome analysis; the phylogeny, evolution and epidemiology of Bordetellae; the bvg regulon; Bordetella adhesins and toxins; Ptl Type III secretions in Bordetella subspecies; Ptl Type IV secretion systems; primary metabolism of physiology; bacteriophage and diversity-generating retroelements; biotechnological applications of the Bordetella pertussis adenylate cyclase toxin; and pertussis vaccines.
The mutation leads to a loss of guanosine triphosphatase activity and thus to adenyl cyclase overactivity and subsequent overproduction of cyclic adenosine monophosphate (cAMP).
The Notice of Allowance was given for the patent entitled, "Guanylate or Guanylyl Cyclase Receptor Agonists for the Treatment of Tissue Inflammation and Carcinogenesis.
Historically adenosine receptors were pharmacologically divided into two subtypes: adenosine A1 receptors, which decreased the adenylyl cyclase activity, and A2 receptors, which increased the adenylyl cyclase activity [2, 3].
Forskohlin (Coleus forskohlii): Adenylyl cyclase is a target enzyme of multiple G-protein-coupled receptors.
The abnormalities affect adenylyl cyclase signaling, a process by which cells communicate, and in some experiments, effects were evident only in male rats.