cyclic AMP-dependent protein kinase

cyclic AMP-dependent protein kinase

[¦sī·klik ¦ā¦em¦pē di¦pen·dənt ‚pro‚tēn ′kī‚nās]
(biochemistry)
A serine/threonine protein kinase that phosphorylates a variety of substrates and regulates many important processes such as cell growth and differentiation and the flow of ions across the cell membrane. Also known as protein kinase A; PKA.
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References in periodicals archive ?
Ogreid, "Arginine 210 is not a critical residue for the allosteric interactions mediated by binding of cyclic AMP to site a of regulatory (RI[alpha]) subunit of cyclic AMP-dependent protein kinase," Journal of Biological Chemistry, vol.
p70 ribosomal protein S6 kinase 1 (S6K1, p70S6K) is a member of the AGC (cyclic AMP-dependent protein kinase, cyclic GMP-dependent protein kinase, and protein kinase C) subfamily of serine/threonine protein kinases.
These may be due to the fact that hPTH stimulates cyclic AMP-dependent protein kinase in a group of bone cells bearing PTH receptors and indirect osteoblasts proliferation (8).
(1989) Ganglioside modulation of cyclic AMP-dependent protein kinase and cyclic nucleotide phosphodiesterase in vitro.
Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase. J.
Synthetic substrate for cyclic AMP-dependent protein kinase. Nature, 1975, 257, 416-418.
Identification of four sites phosphorylated in intact cells and in vitro by cyclic AMP-dependent protein kinase and p34cdc2.
Cyclic AMP-dependent protein kinase (PKA), the first protein kinase with its amino acid sequence and crystal structure being defined [212, 213], has served as the prototypical kinase for the entire eukaryotic protein kinase superfamily (kinome).

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