cyclic GMP


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cyclic GMP

[¦sī·klik ¦jē¦em′pē]
(biochemistry)
A 3′,5′-cyclic ester of guanosine monophosphate that is involved in vision transduction through its direct effects on Na+and Ca2+channels in the plasma membrane of rod cells.
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References in periodicals archive ?
Garcia, "Cyclic GMP phosphodiesterase inhibition alters the glial inflammatory response, reduces oxidative stress and cell death and increases angiogenesis following focal brain injury, " Journal of Neurochemistry, vol.
Indeed, atrial natriuretic peptide is a potent vasorelaxant which activity is mediated by activation of the membrane-bound guanylyl cyclase (Winquist et al., 1984), while SNP, a NO donor, induces vascular smooth muscle relaxation mainly through the activation of the soluble guanylyl cyclase, both pathways leading to the subsequent increase in cyclic GMP levels.
The messenger molecule NO exerted its effects by the stimulation of NO sensitive guanylyl cyclase which led to enhanced production of the intracellular messenger cyclic GMP. Cyclic GMP protected endothelial progenitors from oxidative stress.
Mice treated with sildenafil showed browning of the white fat after just a few days of treatment, which is believed to be the result of high cyclic GMP levels.
Oxygen radical/nitric oxide mediate calcium-dependent hormone action on cyclic GMP system: a novel concept in signal transduction mechanisms.
In the present study, we found that the second messenger cyclic GMP may also be involved in the increase in midgut E-20-M activity (enzyme activity measured by radioassay).
By blocking PDE5, Viagra ensures that more cyclic GMP remains available to stimulate a sexual response.
We have demonstrated that exposure of human endothelial cells to (-)-epicatechin elevates the cellular levels of N[O.sup.*] and cyclic GMP and protects against oxidative stress elicited by proinflammatory agonists.
PDE is a generic term referring to at least 11 distinct families that have been identified as hydrolyzing cAMP or cyclic guanosine 3', 5'-monophosphate (cyclic GMP, or cGMP) and that have unique tissue and subcellular distributions.
Erections occur when a stimulus triggers the release of nitric oxide, which activates cyclic guanosine monophosphate (cyclic GMP), an enzyme that causes the smooth muscle of the penis to relax and blood flow to increase.
Nitric oxide, released from the endothelium as a gas or attached to other molecules, stimulates soluble guanylyl cyclase, producing increased concentrations of cyclic GMP. Depending on the direction of nitric oxide release and the site of cyclic GMP activation, differing biological effects can be observed.

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