Guanosine

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Related to cyclic guanosine monophosphate: Cyclic adenosine monophosphate

guanosine

[′gwän·ə‚sēn]
(biochemistry)
C10H13O5N5 Guanine riboside, a nucleoside composed of guanine and ribose. Also known as vernine.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Guanosine

 

the nucleoside consisting of the carbohydrate ribose and the nitrogen base guanine. Colorless crystals. Molecular weight, 283.26 and melting point. 235° C. Free guanosine is an intermediate product of metabolism. It is a component of nucleic acids and biologically active guanyl nucleotides, GMP, GDP. and GTP. GTP (guanosine triphosphate), an energy-rich phosphorus compound, is a coenzyme of some reactions, such as the amination of inosinic acid and the transference of amino acids to ribosomes during the biosynthesis of protein.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
These drugs facilitate erection by inhibiting the PDE5 enzyme, by blocking the degradation of cyclic guanosine monophosphate (cGMP) in the cavernous smooth muscles.
Nitric oxide synthase (NOS), nitric oxide (NO), soluble guanylyl cyclase (sGC) and cyclic guanosine monophosphate (cGMP) have major roles in penile erection physiology.
Glycerine trinitrate infusion 1ug/kg/min-2ug/kg/min was started to achieve pulmonary vasodilation by increasing cyclic Guanosine Monophosphate in the constricted pulmonary vasculature.4,5 Nebulized through endotracheal tube continuously with Alprostadil (prostaglandin E1) at a rate of 5ml/hour, a potent inhaled pulmonary vasodilator.
Abbreviations B-CLL: B-cell chronic lymphocytic leukemia cGMP: Cyclic guanosine monophosphate ED: Erectile dysfunction GMP: Guanosine monophosphate IL: Interleukin NKT: Natural killer T-cells NO: Nitric oxide NOS: Nitric oxide synthase PDE-Is: Phosphodiesterase inhibitors PDEs: Phophodiesterases PKG: Protein kinase G ROS-Nrf2: Reactive oxygen species-nuclear erythroid 2-related factor 2 SC: Sildenafil citrate sGC: Soluble guanylate cyclase TGF-[beta]: Transforming growth factor-[beta] TNF-[alpha]: Tumor necrosis factor-a Treg: Lymphocyte T regulatory cells.
Cyclic guanosine monophosphate and cyclic guanosine monophosphate-dependent protein kinase II
Activation of GC-C results in an increase in concentrations of cyclic guanosine monophosphate, both extracellularly and intracellularly.

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