cyclic nucleotide phosphodiesterase


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cyclic nucleotide phosphodiesterase

[¦sīk·lik ‚nü·klē·ə‚tīd ‚fäs·fə·dī′es·tə‚rās]
(biochemistry)
Any of a group of enzymes that degrade cyclic nucleotides.
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References in periodicals archive ?
Lugnier, "Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents, " Pharmacology and Therapeutics, vol.
The PDE inhibitory assay was carried out spectrophotometrically using Cyclic Nucleotide Phosphodiesterase Assay Kit (A BIOMOL[R] GREEN Quantizyme[R] Assay System, Enzo Life Sciences, Inc., New York, USA).
Characterization and functional relevance of cyclic nucleotide phosphodiesterase isoenzymes of the human prostate.
Beyersmann, Zn2+ and Cd2+ Increase the Cyclic GMP Level in PC12 Cells by Inhibition of the Cyclic Nucleotide Phosphodiesterase, Toxicology 157, 167 (2001).
Role of cyclic nucleotide phosphodiesterase isoenzymes in contractile responses of denuded rat aorta related to various [Ca.sup.2+] sources.
Conti, "Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D," Proceedings of the National Academy of Sciences of the United States of America, vol.
Lugnier, "Cyclic nucleotide phosphodiesterase (PDE) super-family: a new target for the development of specific therapeutic agents," Pharmacology and Therapeutics, vol.
Murakami-Murofushi, "Cyclic phosphatidic acid influences the expression and regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 cells," Biochemical and Biophysical Research Communications, vol.
The stimulation of bovine epididymal sperm metabolism by cyclic nucleotide phosphodiesterase inhibitors.
Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes.
IBMX, theophylline, and papaverine are not selective for any of the cyclic nucleotide phosphodiesterase isozymes (Thompson, 1993); they inhibit phosphodiesterases that hydrolyze cGMP as well as those that hydrolyze cAMP.