cyclic nucleotide phosphodiesterase


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cyclic nucleotide phosphodiesterase

[¦sīk·lik ‚nü·klē·ə‚tīd ‚fäs·fə·dī′es·tə‚rās]
(biochemistry)
Any of a group of enzymes that degrade cyclic nucleotides.
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References in periodicals archive ?
Cyclic AMP is broken down by cyclic nucleotide phosphodiesterase enzymes, which thus suppress and shorten the cAMP signal.
Characterization and functional relevance of cyclic nucleotide phosphodiesterase isoenzymes of the human prostate.
Beyersmann, Zn2+ and Cd2+ Increase the Cyclic GMP Level in PC12 Cells by Inhibition of the Cyclic Nucleotide Phosphodiesterase, Toxicology 157, 167 (2001).
Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes.
Exogenous cyclic nucleotides or inhibition of cyclic nucleotide phosphodiesterase have been reported to stimulate sperm motility and fertilization of oocytes in vitro [5,23].
Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes.
IBMX, theophylline, and papaverine are not selective for any of the cyclic nucleotide phosphodiesterase isozymes (Thompson, 1993); they inhibit phosphodiesterases that hydrolyze cGMP as well as those that hydrolyze cAMP.