cyclin


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cyclin

[′sī·klin]
(cell and molecular biology)
Any member of a family of proteins that regulate the cell cycle and whose cellular levels rise steadily until mitosis, then fall abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus toward mitosis.
References in periodicals archive ?
Cyclin D1 positivity was noted in 80% of the lymphoid cells.
Expression levels of cyclins (cyclins A1, A2, B1, B2, D1, D2, and F), CDKs (CDK1 and CDK2), and E2Fs (E2F1 and E2F2) increase, whereas cell cycle inhibitors (Cdkn1a and Cdkn2a) decrease in islets of betatrophin-injected mice compared to control-injected mice.
In solid tumors, however, including breast cancers, the overexpression of cyclin E and overexpression of cyclin A have been linked with adverse outcomes [48].
Pestell's group was the first to show that cyclin D1 drives mammary tumor growth in vivo.
Activities of cdks are controlled by association with cyclins and reversible phosphorylation reactions.
The interesting and novel, is that changes in cyclin D2 and D3 detected in the inducible model are dependent on mTORC1 activity.
The stainings of cyclins ([B.sub.1], [D.sub.1) and E-cadherin of MCF-7 control cells are shown in Figures 6a, b and c, respectively.
The incubated cells were harvested and the expressions of cyclin D1 and Bcl-xL were detected at mRNA level by real-time reverse transcription-polymerase chain reaction (RT-PCR) and at protein level by Western blotting.
In mammalian cell lines, cyclin A2, the main controlling factor of the progress of mitosis, is essential for DNA replication during prophase of mitosis, and the transition of pivotal points, such as the G1-S and G2-M phases, have an important regulating effect on cell cycle [19].
By combining palbociclib with autophagy inhibitors in cells that express normal Rb and nuclear cyclin E, the dose of palbociclib was reduced significantly.