cyclin-Cdk complex

cyclin-Cdk complex

[¦sīk·lin ¦sē¦dē¦kā ′käm‚pleks]
(cell and molecular biology)
A complex of the regulatory protein cyclin with the catalytic protein Cdk that regulates the cell cycle by selectively phosphorylating various protein substrates at different stages of the cycle.
References in periodicals archive ?
"Our goal was to obtain structural information about any cyclin-CDK complex," says Nikola P.
The CIP/KIP proteins have broad specificity as compared to INK4 proteins for binding and inhibiting the cyclin-CDK complexes. The activity of cyclin-D-CDK4 is inhibited by these proteins, preventing the Rb phosphorylation during the transition of G1 to S phase and inhibit the activity of cyclin-A-CDK2 and cyclin-E-CDK2 in late G1 and early S phase respectively (Sharpless, 2005).
Both SI and RRI function on the suppression of p53 and its target p21; the latter serves as an inhibitor of G1/S cyclin-CDK complexes [9, 10, 21].
Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol.
Activation of cyclin-CDK complexes plays a central role in cell cycle progression and arrest processes [22,23].
It binds to cyclin-CDK complexes to inhibit their catalytic activity and induce cell-cycle arrest (Coqueret 2003: Fukuchi et al.
It can stop the cell at any point because it inhibits all of the cyclin-CDK complexes that nudge the cell through these various stages of division.
Another mechanism that prevents premature entry into the S phase relies on CDK inhibitors (CKIs) that bind onto cyclin-CDK complexes and disrupt their catalytic centre (Pavletich 1999).