Pharmacogenomics of cyclooxygenases
. Pharmacogenomics 2015; 16: 501-522, doi: 10.2217/pgs.15.6.
However, complete inhibition of cyclooxygenase
activity might be detrimental for the host because cyclooxygenases
are critical for optimal host defense during bacterial infection.
Leahy et al., "Pharmacological and biochemical demonstration of the role of cyclooxygenase
2 in inflammation and pain," Proceedings of the National Acadamy of Sciences of the United States of America, vol.
This might be due to non-selective inhibition of cyclooxygenases
that provides support in the synthesis of prostanoids necessary for generating signals by APCs (Antigen presenting cells) and transmitting these signals to T cells.
Willoughby, Inducible cyclooxygenase
may have anti-inflammatory properties, Nature Medicine, 5(6), 698-701 (1999).
Lin et al., "Specific inhibition of cyclooxygenase
2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis," Journal of Immunology, vol.
Structurally, the two cyclooxygenase
enzymes, COX1 and COX-2, are homodimers of two 70kDa subunits related by a C2 axis of symmetry.
Regional expression of cyclooxygenase
isoforms in the rat kidney in complete unilateral ureteral obstruction.
Effects of the Cyclooxygenase
inhibitor, Piroxican, on tumor response, apoptosis, and angiogenesis in a canine model of human invasive urinary bladder cancer.
In vitro studies were performed to determine the inhibitory benefits of Metabiotics Resveratrol on a full thickness tissue model to reduce expression of the anti-inflammatory enzyme cyclooxygenase
1 [COX1] along with its ability to promote the synthesis of Collagen IVA on the same tissue model.