cyclooxygenase


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cyclooxygenase

[‚sī·klō′äks·ə·jə‚nās]
(biochemistry)
An enzyme that catalyzes the conversion of arachidonic acid into prostaglandins.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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References in periodicals archive ?
Pharmacogenomics of cyclooxygenases. Pharmacogenomics 2015; 16: 501-522, doi: 10.2217/pgs.15.6.
However, complete inhibition of cyclooxygenase activity might be detrimental for the host because cyclooxygenases are critical for optimal host defense during bacterial infection.
Leahy et al., "Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain," Proceedings of the National Acadamy of Sciences of the United States of America, vol.
This might be due to non-selective inhibition of cyclooxygenases that provides support in the synthesis of prostanoids necessary for generating signals by APCs (Antigen presenting cells) and transmitting these signals to T cells.
Willoughby, Inducible cyclooxygenase may have anti-inflammatory properties, Nature Medicine, 5(6), 698-701 (1999).
Lin et al., "Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis," Journal of Immunology, vol.
Structurally, the two cyclooxygenase enzymes, COX1 and COX-2, are homodimers of two 70kDa subunits related by a C2 axis of symmetry.
Regional expression of cyclooxygenase isoforms in the rat kidney in complete unilateral ureteral obstruction.
In vitro studies were performed to determine the inhibitory benefits of Metabiotics Resveratrol on a full thickness tissue model to reduce expression of the anti-inflammatory enzyme cyclooxygenase 1 [COX1] along with its ability to promote the synthesis of Collagen IVA on the same tissue model.