Primers for electron transfer flavoprotein subunit alpha, mitochondrial (ETFa), actin (ACTG2), transgelin (TAGLN), cofilin-1 (CFL1), cyclophilin
A (PPIA), myosin (MYL6), galectin-1 (LGALS1), apolipoprotein A-I (APOA), and control genes ([sz]-actin) were obtained from Shanghai Sangon Company, China.
Numerous novel HCV specific inhibitors such as nucleoside and non nucleoside polymerase inhibitors, protease inhibitors, as well as non HCV specific compounds with antiviral activity such as nitazoxanide, cyclophilin
inhibitors (Debio 025), silibinin are under development in clinical trials.
In the crystals obtained by the Sandoz team, each of five cyclophilin
molecules attaches to one side of each of five cyclosporin molecules.
These diverse therapeutic activities result from CRV431's potent inhibition of cyclophilin
enzymes, which are involved in many disease processes.
The mRNA levels of the a-actin, C3, CFB, NF-[kappa]B (p65 subunit), and cyclophilin
A (housekeeping gene) genes were measured using primers listed in Table 1.
ContraVir Pharmaceuticals announced that the peer-reviewed journal, PLOS ONE, has published ContraVir's research article entitled "The Cyclophilin
Inhibitor CRV431 Inhibits Liver HBV DNA and HBsAg in Transgenic Mice." The article describes a study where Hepatitis B virus transgenic mice were treated with CRV431, a cyclophilin
inhibitor; and/or tenofovir exalidex, a nucleotide prodrug.
The most common mutation described in patients with CVID (seen in approximately 8%-10% of cases) is that involving TNFRSF13B, a gene that encodes for the transmembrane activator and calcium modulator and cyclophilin
ligand interactor (TACI).
In this study, eight genes: ubiquitin (Ubi), [alpha]-tubulin ([alpha]-tub), [beta]-tubulin ([beta]-tub), [beta]-actin ([beta]-act), GAPDH, histone H3 (ht3), eukaryotic elongation factor 1a (eEF1) and cyclophilin
(Cyc) were evaluated as reference genes for drought stress in sugarcane leaves under field conditions of drought stress (SILVA et al.
APRIL exhibits physiological effects by binding to two B-lymphocyte receptors, transmembrane activator and calcium modulator cyclophilin
ligand interactor (TACI) and B-cell maturation antigen (BCMA) which promote B-cell proliferation, stimulate production of immunoglobulin M (IgM) antibodies and survival of plasma cells, stimulate lymphocyte maturation and antibody production [12-14].
Divangahi's team determined that a protein in the mitochondria called cyclophilin
D (CypD) acts as a key checkpoint for T cell activation.
Also, Professor HANkan Westerblad and his research group at Karolinska Institutet have evaluated the effects of NeuroVive's cyclophilin
inhibitors in an experimental model of mitochondrial myopathy.