10 A study was carried out by Elgart, that included four patients with pyoderma gangrenosum unresponsive to treatment with prednisone, cyclosporin
, colchicine, cytoxan, and dapsone.
All patients received initial immunosuppres-sive therapy with prednisolone (P), antimetabolites (mycophenolatemofetil-(MMF), azathioprine-(AZA)) combined with calcineurin inhibitors (CNI; cyclosporin
A-CyA/, tacrolimus-Tac), interleukin-2 receptor antagonists (IL-2ra) or mechanistic target of rapamycin (mTOR) inhibitors (sirolimus(SRL)/ everolimus (EVL)).
induced effects on foetal kidney in albino mice.
Surgeons already use existing drugs such cyclosporin
to achieve the same outcome after a transplant, to stop the body rejecting a donated organ.
The calcium channel blocker, Diltiazem, also blocks the metabolism of cyclosporine by cytochrome oxidase, allowing a decrease in cyclosporin
dosage by approximately 30 to 50% (Martin et al.
, methotrexate, oral corticosteroids, azathioprine,
-induced gingival overgrowth: correlation with dental plaque scores, gingivitis scores, and cyclosporin
levels in serum and saliva.
Low dose cyclosporin
A versus pulsed cyclophosphamide in Behc,et\'s syndrome: a single masked trial.
Oral metronidazole does not improve cyclosporin
A-induced gingival hyperplasia.
Postextraction addition experiments (extracted water vs extracted whole blood or serum) to characterize ion suppression (n = 20) demonstrated < 10% mean ion suppression or enhancement for all analytes and internal standards except for cyclosporin
D (46% suppression).
associated gingival overgrowth in renal transplant recipients.
The agency also noted that simvastatin should not be used along with the following drugs, which can increase the risk of myopathy: itraconazole, ketoconazole, posaconazole, erythromycin, clarithromycin, telithromycin, HIV protease inhibitors, nefazodone, gemfibrozil, cyclosporin