cyclosporin A

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cyclosporin A

[¦sī·klə‚spȯr·ən ′ā]
(biochemistry)
A cyclic peptide produced by some fungi. It inactivates helper T cells, making it useful as an immunosuppressive drug, especially in the prevention of graft rejection in transplantation surgery.
References in periodicals archive ?
10 A study was carried out by Elgart, that included four patients with pyoderma gangrenosum unresponsive to treatment with prednisone, cyclosporin, colchicine, cytoxan, and dapsone.
All patients received initial immunosuppres-sive therapy with prednisolone (P), antimetabolites (mycophenolatemofetil-(MMF), azathioprine-(AZA)) combined with calcineurin inhibitors (CNI; cyclosporin A-CyA/, tacrolimus-Tac), interleukin-2 receptor antagonists (IL-2ra) or mechanistic target of rapamycin (mTOR) inhibitors (sirolimus(SRL)/ everolimus (EVL)).
Surgeons already use existing drugs such cyclosporin to achieve the same outcome after a transplant, to stop the body rejecting a donated organ.
The calcium channel blocker, Diltiazem, also blocks the metabolism of cyclosporine by cytochrome oxidase, allowing a decrease in cyclosporin dosage by approximately 30 to 50% (Martin et al.
Cyclosporin, methotrexate, oral corticosteroids, azathioprine,
Cyclosporin-induced gingival overgrowth: correlation with dental plaque scores, gingivitis scores, and cyclosporin levels in serum and saliva.
Low dose cyclosporin A versus pulsed cyclophosphamide in Behc,et\'s syndrome: a single masked trial.
Oral metronidazole does not improve cyclosporin A-induced gingival hyperplasia.
Postextraction addition experiments (extracted water vs extracted whole blood or serum) to characterize ion suppression (n = 20) demonstrated < 10% mean ion suppression or enhancement for all analytes and internal standards except for cyclosporin D (46% suppression).
Cyclosporin associated gingival overgrowth in renal transplant recipients.
The agency also noted that simvastatin should not be used along with the following drugs, which can increase the risk of myopathy: itraconazole, ketoconazole, posaconazole, erythromycin, clarithromycin, telithromycin, HIV protease inhibitors, nefazodone, gemfibrozil, cyclosporin and danazol.