cyclosporin A

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cyclosporin A

[¦sī·klə‚spȯr·ən ′ā]
(biochemistry)
A cyclic peptide produced by some fungi. It inactivates helper T cells, making it useful as an immunosuppressive drug, especially in the prevention of graft rejection in transplantation surgery.
References in periodicals archive ?
Results: Biochemical and histopathological analysis showed significant kidney injury in rabbits exposed to acute nephrotoxic doses of amphotericin B and cyclosporine.
The patients were randomized to receive cyclosporine or prednisolone and were assessed at 6 weeks and 6 months.
Group B was given Cyclosporine A, 20 mg/kg dissolved in 2 ml of olive oil intraperitoneally for 7 days.
However, dietary management to prevent constipation and Cyclosporine + Ketoconazole was continued for another three weeks.
6 mg BID, a therapeutic dose of cyclosporine, flurazepam, gabapentin, levothyroxine, mirtazapine, oxycodone, prednisone, and premarin.
Group A received cyclosporine (3mg/kg) and group B was treated with tacrolimus (0.
Hypothesis A: Cyclosporine is a potent immunosuppressive agents that act on many cells of the body, including epithelial cells and may cause a decrease in the cell proliferation and increase markers for cell damage.
A potential adverse effect of cyclosporine is that it may aggravate hypertension of pregnancy, and, in a small percentage of patients, it produces a pregnancy that is 3-4 weeks shorter than normal.
Harper was the topical cyclosporine group's mean 11.
Furthermore, cyclobenzaprine and cyclosporine are both available in a 10 mg dose form.
In the study, Zortress prevented acute organ rejection and preserved kidney function while allowing, on average, 60% lower does of the CNI cyclosporine to be used compared with the control regimen of mycophenolic acid (MPA) with full dose cyclosporine and corticosteroids.
It showed that patients taking belatacept had similar graft survival rates to those taking cyclosporine, while maintaining higher kidney function and lower blood pressure and cholesterol.