8 The one half of Hcy is used in synthesis of cysteine via trans-sulfuration by vitamin B6 dependent enzyme, cystathionine
beta synthase (CBS).
Hydrogen sulfide (H[sub]2S) is generated in mammalian tissues from homocysteine and cysteine catalyzed by cystathionine
a-synthase and cystathionine
c-lyase, the key enzymes of the transsulfuration pathway of methionine metabolism.
1,25-dihydroxyvitamin D3 infuences cellular homocysteine levels in murine preosteoblastic MC3T3-E1 cells by direct regulation of cystathionine
The taurine, cysteine and cystathionine
concentrations were determined with L-8900 automatic amino acid analyzer (Hitachi Ltd, Tokyo, Japan) after 0.
He has gained worldwide recognition for his research achievements on thymidylate synthase, cystathionine
P-synthase (enzymes involved in folate, homocysteine metabolism), diagnostic imaging, HIV-1 envelope glycoproteinbased vaccines and enzyme-based targeted therapies for treating autoimmune diseases during his appointments at University of Iowa, GE Global Research, University of Michigan, Scripps--USA andUniversity of Queensland.
Put a line from the homocysteine result bar to the cystathionine
3 creatinine ratio Gas chromatographic analysis of Slight urinary organic acids increase in ketone bodies Plasma amino acids ([micro]mol/L) Alanine 413 152-547 Allo-isoleucine 5 0-5 Arginine 108 10-140 Argininosuccinic acid 2 0-8 Asparagine 63 23-112 Aspartic acid 7 0-24 Citrulline 22 1-46 Cystathionine
< 2 0-3 Glutamic acid 43 5-150 Glutamine 512 254-823 Glycine 272 127-341 Histidine 87 41-125 Isoleucine 95 22-107 Leucine 154 49-216 Lysine 203 48-284 Methionine 37 7-47 Ornithine 64 10-163 Phenylalanine 60 26-91 Serine 163 69-187 Threonine 164 35-226 Tryptophan 60 0-79 Tyrosine 70 24-115 Valine 318 74-321
22] Results suggest that maternal micronutrient imbalance (excess folic acid with vitamin B12 deficiency) leads to lower mRNA levels of methylene tetrahydrofolate reductase (MTHFR) and methionine synthase , but higher cystathionine
b-synthase (CBS) and phosphatidylethanolamine-N methyltransferas (PEMT) as compared to control.
A cardioprotective insight of the cystathionine
y-lyase/hydrogen sulfide pathway.
Homocysteine is an amino acid which is formed as an intermediate product in transformation of methionine to cystathionine
Dose and time-dependent effects of cyanide on thiosulfate sulfurtransferase, 3-mercaptopyruvate sulfurtransferase, and cystathionine
The metabolism of the amino acid homocysteine consists of a vitamin B6-dependent trans-sulfuration pathway involving the enzyme Cystathionine
[beta]-Synthase (CBS) and a folate- and vitamin B12-dependent remethylation pathway involving the enzymes Methylene Tetrahydrofolate Reductase (MTHFR) and methionine synthase deficiencies.