cytomegalovirus

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Related to cytomegalovirus disease: CMV

cytomegalovirus

(sī'təmĕg'əlōvī`rəs), member of the herpesvirus family that can cause serious complications in persons with weakened immune systems and infants. A common virus, it is estimated that up to 80% of Americans carry cytomegalovirus by the time they reach adulthood. Most experience no symptoms or mild symptoms such as enlarged lymph nodes, low fever, and fatigue that may or may not be noticed. Cytomegalovirus is present in body fluids (saliva, semen, cervical secretions, and urine) and can be spread from person to person by sexual contact, kissing, or the sharing of food. It can also be transmitted from mother to fetus. The virus usually remains dormant in the body, but it can reactivate and cause serious symptoms in immunologically suppressed patients, such as those with AIDSAIDS
or acquired immunodeficiency syndrome,
fatal disease caused by a rapidly mutating retrovirus that attacks the immune system and leaves the victim vulnerable to infections, malignancies, and neurological disorders. It was first recognized as a disease in 1981.
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, or in infants whose immune systems are not yet fully developed. An estimated 25% of AIDS patients experience CMV infection, often in the form of a viral retinitis that can lead to blindness. Infants can become infected before birth when the mother becomes infected or experiences a recurrence during pregnancy. In a newborn, CMV can be life-threatening, and it can lead to later complications such as cerebral palsy, blindness, hearing problems, mental retardation, and learning disabilities. The antiviral drugs foscarnet and ganciclovir are used to keep active infections under control.

cytomegalovirus

[¦sīd·ō¦meg·ə·lō′vī·rəs]
(virology)
An animal virus belonging to subgroup B of the herpesvirus group; causes cytomegalic inclusion disease and pneumonia.
References in periodicals archive ?
Cytomegalovirus disease latent and active infection rates during the first trimester after kidney transplantation.
Variable viral clearance despite adequate ganciclovir plasma levels during valganciclovir treatment for cytomegalovirus disease in D+/R-transplant recipients," BMC Infectious Diseases, vol.
Antigenemia for cytomegalovirus in renal transplantation: choosing a cutoff for the diagnosis criteria in cytomegalovirus disease.
3,4) The high burden of HIV disease and the increasing scale-up of HAART provision in South Africa (with patients often initiating treatment at low CD4 counts) suggest that cytomegalovirus disease, whether ocular or systemic, will have a huge impact on HIV-related morbidity and mortality.
Preemptive treatment for cytomegalovirus viremia to prevent cytomegalovirus disease in solid organ transplant recipients.
True (A) or false (B)--click on the correct answer: Gastro-intestinal cytomegalovirus disease in humans manifests only as proctitis.
Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial.
In patients with advanced AIDS, the same symptoms may be seen in cytomegalovirus disease, lymphoma, or disseminated M.
PREVEON, formerly referred to as adefovir dipivoxil or GS 840, is an investigational, orally-administered, once-daily, reverse transcriptase inhibitor currently being studied in a variety of late-stage clinical studies to treat human immunodeficiency virus (HIV) and prevent cytomegalovirus disease.
Comparison of PCR, antigenemia assay, and rapid blood culture for detection and prevention of cytomegalovirus disease after lung transplantation.
Cannon MJ, Davis KE Washing our hands of the congenital cytomegalovirus disease epidemic.
Guidelines for the treatment of cytomegalovirus diseases in patients with AIDS in the era of potent antiretroviral therapy: recommendations of an international panel.

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