cytopathic effect


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cytopathic effect

[¦sīd·ə¦path·ik i‚fekt]
(cell and molecular biology)
A change in the microscopic appearance of cells in a culture after being infected with a virus.
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Cytopathic effect of the herpes simplex virus type 1 appears stereologically as early as 4 h after infection of Vero cells.
The plates were incubated at 37[degrees]C and scored for cytopathic effect daily for 7 to 14 days before terminating the readings.
Microphotographs show an unequivocal human papillomavirus (HPV) cytopathic effect on Papanicolaou test (A) and follow-up biopsy (C, hematoxylin-eosin stain) in a woman infected with HPV 90.
HSV cytopathic effect (intranuclear Cowdry type A inclusions) is identified most reliably in viable squamous epithelium, thus, brushings or biopsy of the ulcer edge, rather than the ulcer base, will have the highest diagnostic yield (Figure 4) [12,14-16].
At ASVL, viral cytopathic effect was observed in viral culture cells from the specimen collected from the woman on October 10; however, immunofluorescent antibody staining was negative for herpes simplex virus (HSV).
We suspected a malignancy, but histopathology of biopsy specimens revealed that the mass exhibited the classic signs of the HSV cytopathic effect, including the presence of intranuclear inclusion bodies, ballooning degeneration of epithelial cells, and a ground-glass appearance of some nuclei.
The antiviral activity of the extract was assessed by total inhibition of cytopathic effect after three-day incubation.
At that time, the most rapid diagnosis was by production of cytopathic effect after subpassage in tissue culture (7), but most coronaviruses were recognized only with the use of human embryo tracheal organ cultures, and viral presence was detected by cessation of ciliary motion, by electron microscopy of nutrient media, or most cumbersome of all, by inoculation and production of colds in human volunteers (8, 9).
BAb and NAb levels were measured by ELISA and viral cytopathic effect (CPE) assays, respectively.
alba extract, and virus yield and infectivity were quantified by cytopathic effect (CPE) assay.
beta]-Santalol was investigated for its antiviral activity against influenza A/HK (H3N2) virus using a cytopathic effect (CPE) reduction method.
Similarly, is the cytopathic effect because of the prior chemoradiation therapy, which can cause damage by both direct cytotoxic effect and treatment-induced ischemia, or is the cytopathic effect related to typical tumor outgrowth of its vascular supply, resulting in ischemic injury?