The present study was conducted to evaluate chromosomal DNA damage, cytotoxicity and cytostasis
status, and plasma 8-OHdG levels and their association with thyroid nodule size and thyroid hormones, in patients with multinodular goiter.
Greer, "Amplified Ras-MAPK signal states correlate with accelerated EGFR internalization, cytostasis
and delayed HER2 tumor onset in Fer-deficient model systems," Oncogene, vol.
induced by GC-C ligands is mediated by cGMP and is also associated with altered expression of cell cycle mediators, including cyclin D, pRb, and p27, that regulate the delay in transition from the G1-S phase (83).
Cinnamic acid induces cytostasis
and a reversal of malignant properties in vitro in the human tumour cells.
In a prior report , we identified tumor cell apoptosis in mice treated with temsirolimus, while in vitro exposure only resulted in cytostasis
. Subsequent studies  showed that in vivo apoptosis correlated with a downregulation of tumor VEGF expression and decrease in neoangiogenesis, suggesting that in vivo tumor cytotoxicity is due to indirect effects of the drugs that may result in increased oxygen and nutrient stress in the tumor microenvironment rather than direct drug-mediated apoptosis.
Inhibition of cryptococcus neoformans replication by nitrogen oxides supports the role of these molecules as effectors of macrophage-mediated cytostasis
Evidence of tumour cell cytostasis
and cytotoxicity was found in macrophage-tumour cell co-cultures in which cytokine and/or lipopolysaccharides (LPS)-stimulated macrophages inhibited metabolic functioning of co-cultured tumour cells (9).