cytotoxic T cell

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cytotoxic T cell

[¦sīd·ə‚täk·sik ′tē ‚sel]
(immunology)
A type of T cell which protects against pathogens that invade host cell cytoplasm, where they cannot be bound by antibodies, by recognizing and killing the host cell before the pathogens can proliferate and escape.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
"A low number of donor-specific cytotoxic T lymphocytes identifies patients in whom the immunosuppressive load can be safely reduced," the investigators concluded.
In addition, IL-10 suppresses the cytotoxic activity of cytotoxic T lymphocytes by the reduction of MHC-I expression in target cells [62].
Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia.
Ying, "Molecular and functional analysis of tyrosinase-related protein (TRP)-2 as a cytotoxic T lymphocyte target in patients with malignant glioma," Journal of Immunotherapy, vol.
Key words: Cytotoxic T lymphocyte antigen-4 (CTLA-4), A49G polymorphism, autoimmunity, idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, chronic lymphocytic leukemia
Primary induction of human CD8+ cytotoxic T lymphocytes and interferon-gamma-producing T cells after smallpox vaccination.
Rotavirus-specific cytotoxic T lymphocytes appear at the intestinal mucosal surface after rotavirus infection.
According to the company, the patent is entitled "Composition and Method for Inducing and Enhancing a Telomerase Reverse Transcriptase-Reactive Cytotoxic T Lymphocyte Response", including claims for peptides that induce or enhance a cytotoxic T cell immune response against the human tumor antigen telomerase reverse transcriptase.
Dorothee et al., "Cutaneous T cell lymphoma reactive CD4+ cytotoxic T lymphocyte clones display a Th1 cytokine profile and use a Fas-independent pathway for specific tumor cell lysis," Journal of Investigative Dermatology, vol.
The patent includes claims covering composition of matter as well as methods of use and also encompass immunogens comprising a CD133 epitope and variants thereof as well as methods of using such immunogens in immunisation and to elicit cytotoxic T lymphocyte responses that are specific for tumour cells expressing HLA-A2.
Absolute counts of CD4+ helper T lymphocytes and CD8+ cytotoxic T lymphocytes show marked depression proportionally (fig-1).
Studies show that in Alopecia areata, failure of this immune privilege results in type 1 cellular immunity mediated by cytotoxic T lymphocytes which attack hair follicles and prevent them from entering the growing phase of the hair cycle.3 These cytotoxic T lymphocytes depend on the Interleukin-15 pathway which utilizes Janus Kinase (JAK) proteins for downstream signaling.
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