When cytotoxic agents
are ordered for the treatment of cancer, the protocols are typically readily available, and the drugs are ordered, dispensed, and administered by specially trained health care professionals.
With over a decade of experience and knowledge in ADC innovation, Seattle Genetics has developed proprietary technology employing synthetic cytotoxic agents
, such as monomethyl auristatin E (MMAE), and stable linker systems that attach these cytotoxic agents
to the antibody.
A total of 27 patients elected to receive a cytotoxic agent
Under the collaboration, the two companies will produce the ADCs using PolyTherics' proprietary TheraPEG[TM] linker technology to site-specifically conjugate Spirogen's potent pyrrolobenzodiazepines ("PBDs") cytotoxic agents
- known as warheads - to antibodies and antibody fragments.
This resulted in increased anti-tumor efficacy at a given dose of a cytotoxic agent
Vintafolide is an investigational, proprietary, injectable SMDC consisting of folate (vitamin B9) linked to a potent vinca alkaloid cytotoxic agent
, desacetylvinblastine hydrazide (DAVLBH).
BIND-014 is a targeted polymeric nanoparticle containing the cytotoxic agent
docetaxel (Taxotere), which is approved in major cancer indications including breast, prostate and lung.
Kadcyla consists of Roche's trastuzumab antibody with ImmunoGen's DM1 cytotoxic agent
attached using one of the company's engineered linkers.
The basic principle of antibody-drug conjugates is to use the antibody moiety for targeting the tumor and for tumor-specific delivery of a cytotoxic agent
Serina Therapeutics' president and chief executive officer, Dr Randall Moreadith, said, 'The ability to target antibodies that are "pay-loaded" with a potent cytotoxic agent
has started to produce the first generation of approved antibody drug conjugates.
Pipeline agents holding the greatest commercial potential include the immunoconjugated monoclonal antibodies Arzerra (ofatumumab; Genmab/GlaxoSmithKline), galiximab (Biogen Idec) and lumiliximab (Biogen Idec), as well as the cytotoxic agent
This resulted in increased anti-tumor efficacy at a given dose of the cytotoxic agent
, and thus might allow physicians to maximize efficacy of reduced cytotoxic agent
doses with resultant decreased toxicity to the normal organs.