Remaining 5 patients with dacryoadenitis
were diagnosed as pseudotumour.
associated with brucellosis.
The histopathological features in IgG4-related sialadenitis and dacryoadenitis
include lymphoplasmacytic infiltrate, IgG4-positive cells, obliterative phlebitis, and fibrosis.
This is a case of a patient presenting with inflammatory dacryoadenitis
and orbital pseudotumor likely as a highly unusual extrahepatic manifestation of HCV infection.
Kise et al., "Effectiveness of imaging modalities for screening IgG4-related dacryoadenitis
and sialadenitis (Mikulicz's disease) and for differentiating it from Sjogren's syndrome (SS), with an emphasis on sonography," Arthritis Research & Therapy, vol.
evolving into an extra-nodal, marginal zone B-cell lymphoma (EMZL): A tale of two lacrimal glands.
(5) Among sclerosing lesions of the orbit, IgG4-secreting plasma cells have been documented in allegedly chronic sclerosing dacryoadenitis
, which in one report served as the soil out of which emerged 3 lacrimal gland IgG4-positive lymphomas (2 extranodal marginal zone and 1 follicular lymphoma).
Other causes of KCS include immunomediated dacryoadenitis
, distemper virus infection (due to inflammation generated by direct action of virus in the conjunctival cells), congenital acinar hypoplasia, chronic blepharoconjunctivitis (due to entropion, ectropion, trichiasis and atopy), protrusion of the third eyelid gland, traumatic proptosis (GRAHN & STOREY, 2004).
Ohta et al., "Lesional CD4+ IFN-[gamma]+ cytotoxic T lymphocytes in IgG4-related dacryoadenitis
and sialoadenitis," Annals of the Rheumatic Diseases, vol.
Yu, "Innate immune signaling induces IL-7 production, early inflammatory responses, and Sjogren's-like dacryoadenitis
in C57BL/6 mice," Investigative Ophthalmology & Visual Science, vol.
Inflammatory lesions consist of pseudotumours (6 patients, 19.35%), dacryoadenitis
(5 patients, 16.13%) and granulomatous inflammation (1 patient, 3.23%).
These include myositis, dacryoadenitis
, scleritis, and perineuritis, all of which appear to be more common in women .