actinomycin

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Related to dactinomycin: Daunorubicin, doxorubicin

actinomycin

(ăk'tənōmī`sən), any one of a group of antibioticsantibiotic,
any of a variety of substances, usually obtained from microorganisms, that inhibit the growth of or destroy certain other microorganisms. Types of Antibiotics
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 produced by bacteria of the genus Streptomyces. Actinomycin was the first antibiotic reported to be able to halt cancer; however, it is not widely used to treat cancers because it is highly toxic to humans, interfering with the genetic material of cells. It is mainly used as an investigative tool in cell biology.

actinomycin

[‚ak·tə·nō′mī·sən]
(microbiology)
The collective name for a large number of red chromoprotein antibiotics elaborated by various strains of Streptomyces.
References in periodicals archive ?
Dactinomycin is an actinomycin indicated for the treatment of: adult and pediatric patients with Wilms tumor, as part of a multi-phase, combination chemotherapy regimen.
The drug formulation includes dactinomycin, a well-understood cancer drug, incorporated into a proprietary ANA-conjugated nanoemulsion.
Standard treatment according to the IRSG/STS COG trials in North America consists of a combination of vincristine, dactinomycin and cyclophosphamide (VAC).
Chemical name Trademarker Class Source Actinomycin-D Dactinomycin Non-alkaloid Streptomyces spp.
Bigmar intends to formulate and market a number of generic oncology drugs in IV bags, including, Fluorouracil, Doxorubicin, Methotrexate, Dacarbazine, Carboplatin, Aclarubicin, Ganciclovir, Azathioprine, Cyclophosphamide, Ifosfamide, Melphalan, Vincristinsulphate, Cisplatin, Amsakrine, Etoposide, Vinblastin and Dactinomycin. In this regard, Bigmar plans to apply for ANDA approvals in the United States as well as various approvals from European regulatory authorities for the above-mentioned generic oncology drugs in IV bags during the first half of 2000.
There has been no acceptable antidote reported in the literature for a dactinomycin infiltrate (Dorr, 1994).
The drug combination VAC (vincristine, dactinomycin, and cyclophosphamide) has been widely studied and found to be effective against this disease.
The patient then was administered combined chemotherapy, including vincristine (2 mg/[m.sup.2], day 1), doxorubicin (75 mg/[m.sup.2], day 1), cyclophosphamide plus mesna (1200 mg/[m.sup.2], day 1), dactinomycin (1.25 mg/[m.sup.2], day 1), ifosfamide plus mesna (1800 mg/[m.sup.2] daily, days 1-5) and etoposide (100 mg/[m.sup.2] daily, days 1-5).
* combination chemotherapy (adriamycin, vinblastine, bleomycin, dactinomycin, vincristine, dacarbazine)
Other important products acquired in the acquisition are NeoProfen (ibuprofen lysine injection) and Indocin IV (indomethacin injection), which is indicated to close a clinically significant patent ductus arteriosus (PDA) in premature infants, and Cosmegen (dactinomycin for injection), used mainly in the treatment of three rare cancers.
Alternative drug, dactinomycin (0.5 mg), is recommended to infuse into uterine artery of the literature [13].
Bedford Laboratories, a division of Ben Venue Laboratories Inc., has added dactinomycin for injection USP 500 mcg (0.5 mg) to its line of generic oncology products.