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Dapsone was given for a total period of six months, initially 100 mg daily for four months then 50 mg daily for another two months.
Biopsy results of 20 US leprosy patients known to be originally from other locations given diagnoses during this time interval did not demonstrate dapsone or rifampin resistance.
The pathogenesis remains unknown and it was presumed that metabolites of dapsone, could form haptens with the production of anti-dapsone antibodies.
Patients who had G6PD deficiency and were not started on Dapsone therapy, showed recurrences else all the patients were normal.
Recently, an HLA class I allele, HLA-B* 13:01, has been identified as a marker of susceptibility to DIHS attributable to dapsone (dapsone hypersensitivity syndrome) [52-54].
He was started on oral prednisolone 20mg daily and dapsone 25mg daily later decreased to 25mg/day and then withheld after 2 weeks due to anemia.
Most cases reported in the literature had a similar outcome to that in our patient, complete remission being achieved following a course of prednisone and dapsone.  One such case report described a 10-month-old white child with LABD with a similar presentation to our patient, but with no fever or mucosal signs.
Newer classes of medications also are diversifying therapeutic options, including topical dapsone gel in children 12 years and older.
Dapsone gel, 7.5%, marketed as Aczone gel, 7.5%, by Allergan, is a once-daily reformulation of the older 5% product administered twice daily.
In addition to discussing the implications of the FDA's unprecedented approval of a full prescription--strength topical retinoid for OTC use, he highlighted other developments in topical therapy for acne, including the 2016 approval of dapsone 7.5% gel, as well as several agents with novel mechanisms of action now wending their way through the developmental pipeline.
At the time of blood collection, all patients were being treated with glucocorticoids (GCs); prednisone and dapsone were the most commonly used, at doses of 5-60 mg/day and 80-150 mg/day, respectively.
The isolates from these two towns (Nsawam and Amasaman) in addition to the reference strains were tested against eight selected antimicrobial agents, namely, amikacin, azithromycin, dapsone, ciprofloxacin, clofazimine, ofloxacin, rifampicin, and streptomycin.
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- Danush Shaverdian
- Danville, Jean Baptiste
- Danysz reaction
- Daoud, Sardar Muhammad
- DAP Fortran
- Daphnis and Chloë
- dapped beam
- Daquin, Louis Claude
- D'Aquino, Iva Ikuko Toguri
- D'Aquino, Iva Toguri
- Dar es Salaam
- DAR State Forest
- Dara, Gavril
- Daragona, Ludovico
- Darbee Visual Presence
- D'Arblay, Madame
- Darbois de Jubainville, Henri
- D'Arbonne National Wildlife Refuge
- Darboux, Jean Gaston
- Darboux's monodromy theorem
- Darboy, Georges
- Darby and Joan
- Darby, John Nelson
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- dapsone neuropathy
- Dapto High School
- daptor-related protein complex 3, sigma 1 subunit