By studying these systems, we will uncover much more information on how stem cells contribute to regeneration, the issue of de-differentiation
that is a common theme in these organs and the effect this might have on the origin of cancer.
Exact origin of melanoma in GCTs is unknown but these may occur from transformation of dermal elements or de-differentiation
of germ cells to melanomas.
10] suggest that one possible explanation could be the occurrence of de-differentiation
GBM frequently arises de novo, but may develop from diffuse or anaplastic astrocytomas that undergo de-differentiation
However, no experiments published have directly demonstrated this de-differentiation
process, so Li and his research team remained skeptical.
Stem cell scientists in China have used a technique known as de-differentiation
to re-engineer cells to a more primitive state that increases cell survival rates and offers greater potential for clinical use.
The unit prevents de-differentiation
of adult cardiomyocytes, encourages pre-commitment of stem cells toward certain muscle phenotypes and is suited for cardiac tissue engineering.
In particular, he discusses the definition and classification of cancer, cellular carcinogenesis as a monoclonal multi-step threshold phenomenon, the five types of genetic and molecular changes leading to cancer, causes of cancer, cellular changes associating malignant transformation or de-differentiation
, tumor recurrence and metastasis, tumor markers, natural inhibitors of the multi-stage carcinogenesis, and biochemical bases of current anti-cancer treatments.
Having learnt some lessons from SCNT (cloning), we need to be very cautious in generating stem cells by directed differentiation (IPS) or de-differentiation
for cell therapy to treat diseases.
Perhaps the biggest factor is the expansion of the knowledge economy itself, which has profoundly altered social relationships between individuals and also at the macro-level, resulting in a de-differentiation
of roles and making subjectivities such as the consumer-citizen more readily available.
It is one thing to point out that "deconstruction" is quite as interested in de-differentiation
as in its converse, but to suggest that Caliban (prosopopoeia) is always already proven to have been behind Ariel (psyche) might be more than the tradition, granted its tempest and its tears, normally would want to put up with.
If germ cells can be derived from patients' own adult cells using de-differentiation
followed by germ cell differentiation, this adds an important strategy available to treat infertility.