Zhu et al., "Polymyxin-induced lipid A deacylation
in Pseudomonas aeruginosa perturbs polymyxin penetration and confers high-level resistance," ACS Chemical Biology, vol.
Recent studies have also shown that Sirtuin 3 induces mitochondrial dysfunction by enhancing ceramide biosynthesis via deacylation
of ceramide synthase .
Phosphatidylcholine (PtdCho) and phosphatidylethanolamine (similarly to phosphatidylinositol, Ptdlns) can generate second messengers such as diacylglycerol (DAG) and phosphatidic acid, which in turn is a precursor of DAG, lysophosphatidic acid, and arachidonic acid, through three major catabolic pathways, respectively, mediated by specific phospholipases of type C (PLC) and D (PLD), acting at the two distinct phosphodiester bonds of the phospholipid headgroup and by phospholipase A2 (PLA2) in the deacylation
reaction cascade .
Kudo et al., "Kinetic and structural basis for acyl-group selectivity and [NAD.sup.+] dependence in sirtuin-catalyzed deacylation
," Biochemistry, vol.
LPA is produced by fatty acid deacylation
of phosphatidic acid (PA) by [PLA.sub.2] (or [PLA.sub.1]), or by removal of the polar head group of lysophosphatidylcholine (LPC), which is produced from PC by [PLA.sub.2] (or [PLA.sub.1]), by a lysophospholipase D termed autotaxin (ATX).
Denu, "Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation
by Mammalian Sirtuins," The Journal of Biological Chemistry, vol.
(checked by TLC, hexane/ethyl acetate, 7:3, v/v), water was removed with anhydrous sodium sulfate, the mixture was filtered, and the solvent was removed under reduced pressure.
found that the deacylation
activity of the mutation Q50[beta]M-Y149[alpha]K-F177[alpha]G toward CPC improved by 7.9-fold (16).
The first stage occurring at the range of 300-400[degrees]C is related to the expansion of EG and the deacylation
of the EVA phase through radical and ionic [beta]-elimination mechanism [34, 35].
For instance, enantioselective interesterification and transesterification reactions by the help of lipases have great significance in pharmaceutical industry for selective acylation and deacylation