deacylation

deacylation

[dē‚as·ə′lā·shən]
(organic chemistry)
Removal of an acyl group from a compound.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Zhu et al., "Polymyxin-induced lipid A deacylation in Pseudomonas aeruginosa perturbs polymyxin penetration and confers high-level resistance," ACS Chemical Biology, vol.
Recent studies have also shown that Sirtuin 3 induces mitochondrial dysfunction by enhancing ceramide biosynthesis via deacylation of ceramide synthase [63].
Phosphatidylcholine (PtdCho) and phosphatidylethanolamine (similarly to phosphatidylinositol, Ptdlns) can generate second messengers such as diacylglycerol (DAG) and phosphatidic acid, which in turn is a precursor of DAG, lysophosphatidic acid, and arachidonic acid, through three major catabolic pathways, respectively, mediated by specific phospholipases of type C (PLC) and D (PLD), acting at the two distinct phosphodiester bonds of the phospholipid headgroup and by phospholipase A2 (PLA2) in the deacylation reaction cascade [33].
Kudo et al., "Kinetic and structural basis for acyl-group selectivity and [NAD.sup.+] dependence in sirtuin-catalyzed deacylation," Biochemistry, vol.
LPA is produced by fatty acid deacylation of phosphatidic acid (PA) by [PLA.sub.2] (or [PLA.sub.1]), or by removal of the polar head group of lysophosphatidylcholine (LPC), which is produced from PC by [PLA.sub.2] (or [PLA.sub.1]), by a lysophospholipase D termed autotaxin (ATX).
Denu, "Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by Mammalian Sirtuins," The Journal of Biological Chemistry, vol.
After deacylation (checked by TLC, hexane/ethyl acetate, 7:3, v/v), water was removed with anhydrous sodium sulfate, the mixture was filtered, and the solvent was removed under reduced pressure.
found that the deacylation activity of the mutation Q50[beta]M-Y149[alpha]K-F177[alpha]G toward CPC improved by 7.9-fold (16).
The first stage occurring at the range of 300-400[degrees]C is related to the expansion of EG and the deacylation of the EVA phase through radical and ionic [beta]-elimination mechanism [34, 35].
For instance, enantioselective interesterification and transesterification reactions by the help of lipases have great significance in pharmaceutical industry for selective acylation and deacylation reactions [141].
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