deamidation


Also found in: Medical, Wikipedia.

deamidation

[dē‚am·ə′dā·shən]
(organic chemistry)
Removal of the amido group from a molecule.
References in periodicals archive ?
Composition, protein digestibility and deamidation in Brazilian soy cultivars subjected to gamma radiation.
Biochemical tests (niacin production, nitrate reduction, thiophen-2-carboxylic acid anhydride susceptibility, and pyrazinamidase deamidation) were used for identification of M.
The comparison of two structures of the mesophilic and hyperthermophilic endoglucanase, Crennell's study mentioned that large increase in the number of ion pairs and the stabilisation of a highly mobile loop on the periphery of the active site, together with sequence changes to counter deamidation appeared to be major features contributing to the increased thermostability.
Other changes such as post translational modifications of individual amino acids through, oxidation, deamidation, isomerization, etc.
The acidic AAs, i.e., Asp and Glu, underwent slight concentration increases in all DBSs stored at 25 [degrees]C for 6 days and at lower temperatures for 30 days, which might be because of contributions from deamidation of Asn and Gln and/or protein hydrolysis.
Dyer et al., "Modeling deamidation in sheep alpha-keratin peptides and application to archeological wool textiles," Analytical Chemistry, vol.
Its proteins are affected by a large number of PTMs such glycosylation, phosphorylation, acetylation, ubiquitination, methylation, deamidation, sulfation, or proteolysis.
Tau is also extensively modified posttranslationally and has been reported to be modified by phosphorylation, acetylation, glycosylation, glycation, deamidation, isomerization, nitration, methylation, ubiquitylation, sumoylation, and truncation.[12] The largest tau isoform (tau 441) can be phosphorylated at numerous serine/threonine and tyrosine residues.[13] Ser/thr motifs preceding a proline residue are phosphorylated by proline-directed protein kinases (PDPKs) such as glycogen synthase kinase-3[sz] (GSK-3[sz]), cyclin-dependent-like kinase-5 (CDK5), and dual specificity tyrosine-phosphorylation-regulated kinase 1A.
Most polypeptide drugs are sensitive to pH variety in GIT, and pH variation results in pH-induced oxidation, deamidation, and hydrolysis reactions which constitute chemical barriers to absorption (15).
In addition, Catalent Biologics analytical services will be showcasing expert posters on The Use of LC-MS to Monitor Levels of Oxidation and Deamidation in Proteins for Release and Stability by Anne Marie Rogan, Senior Associate Scientist and Quantitation and Characterization of Polysorbate-80 by HPLC and Charged Aerosol Detection by Luke Deters, Senior Manager, Large Molecule Analytical Chemistry.
Oxidation of methionine, deamidation of asparagine and glutamine, deimination (citrullination) of arginine, and propionamide of cysteine were specified in Sequest as variable modifications.