of tertiary amines using phosgene or triphosgene: an efficient and rapid procedure for the preparation of carbamoyl chlorides and unsymmetrical ureas.
In the present study we monitored CYP3A4 activity by the debenzylation
of luciferin 6' benzyl ether into luciferase substrate.
Catalytic hydrogenation of 3 affected both debenzylation
and the desired partial reduction of the furanone ring system to produce 5, a formal precursor to 1 (Saniere et al.
, they were converted to HC1 salts.
of 19b by hydrogenation afforded 21 with a free phenolic group in good yield.