Regarding vanadium toxicity, it has been shown that it is dramatically reduced when oligomerized in the form of decavanadate [20-23].
Then, four drops of concentrated hydrochloric acid (37%) at room temperature were added to allow decavanadate anion formation at pH 6.
Metformin decavanadate has shown hypoglycemic and hypolipidemic effects on models of type 1 and type 2 diabetes mellitus.
Despite the fact that the physiological pathways are unclear, it is now known that vanadate has different pharmacokinetics compared to the decavanadate and therefore different pharmacological activities, although, in relation with the carbohydrate and lipid metabolism, these act very similar.
By contrast, metforminium decavanadate (MetfDeca) presented in Figure 1 showed an improvement in the intracellular biochemical behavior and also a recovering of the adequate levels of lipids and carbohydrates .
Isopolyanions (e.g., decavanadate) may be a good candidate.
Preparation of Decavanadate. The decavanadate ([K.sub.6][V.sub.10][O.sub.28] x 9[H.sub.2]O) was prepared according to a described procedure .
McLauchlan et al., "Inhibitory effects of decavanadate
on several enzymes and Leishmania tarentolae in vitro," Journal of Inorganic Biochemistry, vol.
The number of review papers and chapters reporting decavanadate biochemistry and biological activities has clearly increased since 2005 [1-5].
Decavanadate ([V.sub.10]) species are usually not taken into account in vanadium toxicological studies, although they are well known to affect the activity of several enzymes and to impact lipidic structures .
Aureliano covers recent advances in the understanding of decavanadate toxicology and pharmacological applications.
presents metforminium decavanadate (MetfDeca) as a potential metallopharmaceutical drug for the treatment of diabetes mellitus.