Second, amphibians have retained limb regeneration-specific genes not found in mammals, which allowtheir cells to dedifferentiate
Caption: Figure 1: Phase contrast microscopy of human subcutaneous mature adipocytes undergoing dedifferentiate
at various stages (4x) in ceiling culture at days 4, 7, and 12.
Following injury, Muller glia cells dedifferentiate
into a stemlike state and proliferate to replace lost retinal cells .
During gut regeneration, the specialized epithelial cells dedifferentiate
, re-enter the cell cycle, and migrate either as an epithelial sheet or as single cells.
Spinal Cord Society (Fergus Falls, MN) has patented a process for generating multipotent cells from glial cells using in vitro techniques to dedifferentiate
fetal or adult mammalian glial cells into multipotent cells.
After injury, mature kidney cells dedifferentiate
into more primordial versions of themselves, and then differentiate into the cell types needing replacement in the damaged tissue.
Evidence from studies in small animals suggests that following physical injury the cells bordering the lesion dedifferentiate
, flatten, proliferate, and migrate over the denuded area to restore the barrier function of the epithelium [2-8].
Simultaneously with migration and proliferation, the cells of the stomach lining continue to dedifferentiate
. As a result, by day 7 after autotomy the hole on the aboral side of the disk is closed and the digestive system is replaced.
It is possible, however, for these tumors to dedifferentiate
further into a more aggressive form, with the possibility of metastasis.
The most significant seems to be that the worms do not dedifferentiate
cells to create the blastema.
Prior to migration, the cells seem to dedifferentiate
. The primitive lumen of the new alimentary canal initially arises in a short region of the anterior rudiment lying just posterior to the regrowing aquapharyngeal bulb.
The researchers say the next steps include testing the process on human muscle tissue and screening for other molecular compounds that could help dedifferentiate