dedifferentiation


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dedifferentiation

[dē‚dif·ə‚ren·chē′ā·shən]
(biology)
Disintegration of a specialized habit or adaptation.
(cell and molecular biology)
Loss of recognizable specializations that define a differentiated cell.
(physiology)
Return of a specialized cell or structure to a more general or primitive condition.
References in periodicals archive ?
Well-differentiated liposarcoma of the retroperitoneum: a clinicopathologic analysis of 20 cases, with particular attention to the extent of low grade dedifferentiation.
The organogenesis was only observed in the base of the leaf explants, in response to NAA and BA, probably because of the activation of competent cells to the dedifferentiation, which highlights the morphogenic potential of this region.
Based on analyses of several markers of Schwann cell dedifferentiation and proliferation, these authors concluded that [H.
Ma and Wu (2008) suggested that explant damage during excision of cotyledonary nodes can easily cause dedifferentiation into callus if sub-cultured on media supplemented with high concentrations (greater than 3 mg L-1) of BA.
The answer is simple: Pierre Schlag's The Dedifferentiation Problem seems to provide another way to understand the source of the incompleteness and possible incoherence in Kennedy's thought that first puzzled me back in Critical Legal Studies days, puzzled me when first writing about Three Globalizations, and, I might add, still puzzles me now, since Kennedy's thought is normally so clear and cogent.
It has been reported that chondrocytes expanded in culture gradually undergo dedifferentiation and loose morphological features as well as specialized functions.
The dedifferentiation of contractile and quiescent SMCs to migratory, proliferative, and synthetic phenotype in the intima has been implicated in the development of atherosclerosis.
According to the authors, a mysterious process triggers residual cells to revert to a less developed state upon tissue damage, a process known as dedifferentiation and understanding the mechanisms could support the design of regenerative therapies that direct human cells to behave similarly and perfectly restore lost tissue.
Thymoma and lupus: apropos of a case with recurrences and histological dedifferentiation.
In addition, local release of TNF[alpha] and IL-[beta] from macrophages with dedifferentiation of adipocytes was found (4).
Tissue culture imposes stress to plant tissues during dedifferentiation and differentiation processes ultimately resulting in somaclonal variation and DNA modification (Labra et al.
Dedifferentiation of prostate cancer grade with time in men followed expectantly for stage T1c disease.