dedifferentiation


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dedifferentiation

[dē‚dif·ə‚ren·chē′ā·shən]
(biology)
Disintegration of a specialized habit or adaptation.
(cell and molecular biology)
Loss of recognizable specializations that define a differentiated cell.
(physiology)
Return of a specialized cell or structure to a more general or primitive condition.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Molecular profiling study of a recurrent ovarian mucinous tumour with a mural nodule of anaplastic carcinoma, providing supportive evidence of dedifferentiation. Pathology 2016; 48: S143.
Together, these findings provide a rationale for exploring the causal relationship between dedifferentiation and cancer development using iPSC technology.
It can be concluded that increased tumor dedifferentiation caused an increase in the number of nuclei, and a decrease of other histological elements.
The mechanism by which CSCs originate is (either) by normal SCs that underwent genetic and epigenetic changes and (or) by dedifferentiation from somatic tumour cells [19].
Cortese, "Hepatocyte dedifferentiation and extinction is accompanied by a block in the synthesis of mRNA coding for the transcription factor HNF1/ LFB1," The EMBO Journal, vol.
The clinicopathological features of WDTC patients undergoing dedifferentiation are poorly characterized.
Alternatively, it was suggested that elderly adults might present a more nonselective recruitment of brain regions ("dedifferentiation hypothesis"; [22]).
Foci of DTC are found in 20-30% of ATC suggesting that ATC may develop as a result of dedifferentiation of pre-existing DTC.
Weiss, "Dedifferentiated liposarcoma: a clinicopathological analysis of 155 cases with a proposal for an expanded definition of dedifferentiation," The American Journal of Surgical Pathology, vol.
While the individual withers under conditions of radical autonomy, she thrives through the intensification and continuous variation (i.e., reorganization) of the connections binding self to world As Lenin observed in a philosophical fragment on dialectics, it is through a kind of robust and positive intersectionality, not through dedifferentiation and generality, that the individual is able to partake of the universal: "Every individual enters incompletely into the universal, etc., etc.
This unique tissue consists of stem/progenitor cells as a consequence of dedifferentiation and accumulation events, which take place at the cut or wound site.