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nervous system

nervous system, network of specialized tissue that controls actions and reactions of the body and its adjustment to the environment. Virtually all members of the animal kingdom have at least a rudimentary nervous system. Invertebrate animals show varying degrees of complexity in their nervous systems, but it is in the vertebrate animals (phylum Chordata, subphylum Vertebrata) that the system reaches its greatest complexity.

Anatomy and Function

In vertebrates the system has two main divisions, the central and the peripheral nervous systems. The central nervous system consists of the brain and spinal cord. Linked to these are the cranial, spinal, and autonomic nerves, which, with their branches, constitute the peripheral nervous system. The brain might be compared to a computer and its memory banks, the spinal cord to the conducting cable for the computer's input and output, and the nerves to a circuit supplying input information to the cable and transmitting the output to muscles and organs.

The nervous system is built up of nerve cells, called neurons, which are supported and protected by other cells. Of the 200 billion or so neurons making up the human nervous system, approximately half are found in the brain. From the cell body of a typical neuron extend one or more outgrowths (dendrites), threadlike structures that divide and subdivide into ever smaller branches. Another, usually longer structure called the axon also stretches from the cell body. It sometimes branches along its length but always branches at its microscopic tip. When the cell body of a neuron is chemically stimulated, it generates an impulse that passes from the axon of one neuron to the dendrite of another; the junction between axon and dendrite is called a synapse. Such impulses carry information throughout the nervous system. Electrical impulses may pass directly from axon to axon, from axon to dendrite, or from dendrite to dendrite.

So-called white matter in the central nervous system consists primarily of axons coated with light-colored myelin produced by certain neuroglial cells. Nerve cell bodies that are not coated with white matter are known as gray matter. Nonmyelinated axons that are outside the central nervous system are enclosed only in a tubelike neurilemma sheath composed of Schwann cells, which are necessary for nerve regeneration. There are regular intervals along peripheral axons where the myelin sheath is interrupted. These areas, called nodes of Ranvier, are the points between which nerve impulses, in myelinated fibers, jump, rather than pass, continuously along the fiber (as is the case in unmyelinated fibers). Transmission of impulses is faster in myelinated nerves, varying from about 3 to 300 ft (1–91 m) per sec.

Both myelinated and unmyelinated dendrites and axons are termed nerve fibers; a nerve is a bundle of nerve fibers; a cluster of nerve cell bodies (neurons) on a peripheral nerve is called a ganglion. Neurons are located either in the brain, in the spinal cord, or in peripheral ganglia. Grouped and interconnected ganglia form a plexus, or nerve center. Sensory (afferent) nerve fibers deliver impulses from receptor terminals in the skin and organs to the central nervous system via the peripheral nervous system. Motor (efferent) fibers carry impulses from the central nervous system to effector terminals in muscles and glands via the peripheral system.

The peripheral system has 12 pairs of cranial nerves: olfactory, optic, oculomotor, trochlear, trigeminal, abducent, facial, vestibulo-cochlear (formerly known as acoustic), glossopharyngeal, vagus, spinal accessory, and hypoglossal. These have their origin in the brain and primarily control the activities of structures in the head and neck. The spinal nerves arise in the spinal cord, 31 pairs radiating to either side of the body: 8 cervical, 12 thoracic, 5 lumbar, 5 sacral, and 1 coccygeal.

Autonomic Nervous System

The autonomic nerve fibers form a subsidiary system that regulates the iris of the eye and the smooth-muscle action of the heart, blood vessels, glands, lungs, stomach, colon, bladder, and other visceral organs not subject to willful control. Although the autonomic nervous system's impulses originate in the central nervous system, it performs the most basic human functions more or less automatically, without conscious intervention of higher brain centers. Because it is linked to those centers, however, the autonomic system is influenced by the emotions; for example, anger can increase the rate of heartbeat. All of the fibers of the autonomic nervous system are motor channels, and their impulses arise from the nerve tissue itself, so that the organs they innervate perform more or less involuntarily and do not require stimulation to function.

Autonomic nerve fibers exit from the central nervous system as part of other peripheral nerves but branch from them to form two more subsystems: the sympathetic and parasympathetic nervous systems, the actions of which usually oppose each other. For example, sympathetic nerves cause arteries to contract while parasympathetic nerves cause them to dilate. Sympathetic impulses are conducted to the organs by two or more neurons. The cell body of the first lies within the central nervous system and that of the second in an external ganglion. Eighteen pairs of such ganglia interconnect by nerve fibers to form a double chain just outside the spine and running parallel to it. Parasympathetic impulses are also relayed by at least two neurons, but the cell body of the second generally lies near or within the target organ.

The Nervous System and Reflexes

In general, nerve function is dependent on both sensory and motor fibers, sensory stimulation evoking motor response. Even the autonomic system is activated by sensory impulses from receptors in the organ or muscle. Where especially sensitive areas or powerful stimuli are concerned, it is not always necessary for a sensory impulse to reach the brain in order to trigger motor response. A sensory neuron may link directly to a motor neuron at a synapse in the spinal cord, forming a reflex arc that performs automatically. Thus, tapping the tendon below the kneecap causes the leg to jerk involuntarily because the impulse provoked by the tap, after traveling to the spinal cord, travels directly back to the leg muscle. Such a response is called an involuntary reflex action.

Commonly, the reflex arc includes one or more connector neurons that exert a modulating effect, allowing varying degrees of response, e.g., according to whether the stimulation is strong, weak, or prolonged. Reflex arcs are often linked with other arcs by nerve fibers in the spinal cord. Consequently, a number of reflex muscle responses may be triggered simultaneously, as when a person shudders and jerks away from the touch of an insect. Links between the reflex arcs and higher centers enable the brain to identify a sensory stimulus, such as pain; to note the reflex response, such as withdrawal; and to inhibit that response, as when the arm is held steady against the prick of a hypodermic needle.

Reflex patterns are inherited rather than learned, having evolved as involuntary survival mechanisms. But voluntary actions initiated in the brain may become reflex actions through continued association of a particular stimulus with a certain result. In such cases, an alteration of impulse routes occurs that permits responses without mediation by higher nerve centers. Such responses are called conditioned reflexes, the most famous example being one of the experiments Ivan Pavlov performed with dogs. After the dogs had learned to associate the provision of food with the sound of a bell, they salivated at the sound of the bell even when food was not offered. Habit formation and much of learning are dependent on conditioned reflexes. To illustrate, the brain of a student typist must coordinate sensory impulses from both the eyes and the muscles in order to direct the fingers to particular keys. After enough repetition the fingers automatically find and strike the proper keys even if the eyes are closed. The student has “learned” to type; that is, typing has become a conditioned reflex.

Disorders of the Nervous System

A number of diseases can significantly affect the proper functioning of the nervous system. Parkinson's disease, Huntington's disease, myasthenia gravis, and amyotrophic lateral sclerosis (commonly known as Lou Gehrig's disease) are some of the more severe diseases affecting the nervous system. Strokes, which are related to circulatory disorders, also may have permanent effects on the nervous system. Certain plant derivatives, such as belladonna, cocaine, and caffeine, have a variety of stimulatory, inhibitory, and hallucinatory effects on the nervous system.


See D. Ottoson, Physiology of the Nervous System (1982); G. Chapouthier and J. J. Matras, The Nervous System and How It Functions (1986); L. S. Kee, Introduction to the Human Nervous System (1987); P. Nathan, The Nervous System (3d ed. 1988); J. G. Panavelas et al., ed. The Making of the Nervous System (1988).

The Columbia Electronic Encyclopedia™ Copyright © 2022, Columbia University Press. Licensed from Columbia University Press. All rights reserved.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



the cordlike association of nerve tissues that links the brain and nerve ganglia by innervation to the other organs and tissues of the body.

A nerve primarily consists of nerve fibers. In vertebrates many nerves converge to form a bundle that is surrounded by a connective tissue sheath, the perineurium; the thin interstitial layers of connective tissue that separate the individual fibers deep within the bundle constitute the endoneurium. Finally, the entire nerve trunk, comprising several bundles, is covered by an additional sheath, the epineurium.

Nerves can be sensory (also called afferent or centripetal) or motor (also called efferent or centrifugal). Some nerves, for example, those innervating the skeletal muscles, mainly include myelinated, or medullated, fibers; others, for example, the sympathetic nerves, largely consist of unmyelinated, or unmedullated, fibers.

In reptiles, birds, mammals, and man 12 pairs of cranial nerves branch from the brain: the olfactory (cranial nerve I), the optic (cranial nerve II), the oculomotor (cranial nerve III), the trochlear (cranial nerve IV), the trigeminal (cranial nerve V), the abducent (cranial nerve VI), the facial (cranial nerve VII), the acoustic (cranial nerve VIII), the glossopharyngeal (cranial nerve IX), the vagus (cranial nerve X), the accessory (cranial nerve XI), and the hypoglossal (cranial nerve XII). Only the first ten pairs are present in fish and amphibians.

In man there are 31 pairs of spinal nerves: eight cervical, 12 thoracic, five lumbar, five sacral, and one coccygeal. Each pair innervates the effectors and receptors of a certain part of the body. The spinal nerves branch from the spinal cord into two roots—the posterior, or sensory, and the anterior, or motor. Both roots then combine to form a common trunk that consists of both sensory and motor fibers.

Several adjacent nerves can be combined into nerve plexuses, where an exchange of fibers between different nerves can take place. Three large plexuses are distinguished: the cervical, the brachial, and the lumbosacral. Each nerve plexus is the origin of several pairs of nerves; for example, the sacral portion of the lumbosacral plexus gives rise to the sciatic nerves.

Nerves that originate in the ganglia, trunks, and plexuses of the autonomic nervous system constitute a specific group. The optic nerve is remarkable for its large number of fibers; there are more than 1 million in the human optic nerve. Usually, however, there are 103 -104 fibers in a nerve. In invertebrates certain nerves are known to consist of only a few fibers. The peripheral nervous system in animals and man consists of aggregations of nerves.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.


A bundle of nerve fibers or processes held together by connective tissue.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.


Any one of the ribs of a groined vault, but esp. a rib which forms one of the sides of a compartment of the groining.
McGraw-Hill Dictionary of Architecture and Construction. Copyright © 2003 by McGraw-Hill Companies, Inc.


1. any of the cordlike bundles of fibres that conduct sensory or motor impulses between the brain or spinal cord and another part of the body
2. a large vein in a leaf
3. any of the veins of an insect's wing
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
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tibial nerve 3-5 ml, for Indications: Procedures the deep peroneal nerve, of the foot.
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