demyelinating disease


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demyelinating disease

[dē′mī·ə·lə‚nād·iŋ di‚zēz]
(medicine)
Any disease associated with the destruction or removal of myelin from nerves.
References in periodicals archive ?
Theiler's murine encephalomyelitis virus-(TMEV-) induced demyelinating disease (TMEV-IDD), another popular model for MS, is induced by intracerebral injection with TMEV resulting in CNS inflammation [28].
Multiple sclerosis is a demyelinating disease of the CNS, which typically takes a relapsing-remitting course.
Tumor-mimicking conditions from several etiologic categories are presented in tabular form, including infection and inflammation, demyelinating disease, vascular disease, and posttreatment conditions, with accompanying illustrations and discussion of the current and pertinent literature.
Unlike other biologics approved for psoriasis, it isn't associated with opportunistic infections, heart failure, demyelinating diseases, psoriasis rebound, or reactivation of tuberculosis after the completion of treatment.
Given the public concern over this issue, further studies of a possible association between the vaccine and demyelinating disease are underway at the CDC and in Europe.
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) with a complex etiology.[sup][1] The pathogenesis of MS is not completely understood, and it is believed that a combination of genetic, environmental, and infectious factors trigger autoimmune activity and cause MS onset.[sup][2] Experimental autoimmune encephalomyelitis (EAE) is a mouse model for MS, wherein disease is mediated by CD4[sup]+ T helper cells, macrophages, and other immune cells.[sup][3]
Central nervous system vasculitis rather than demyelinating disease was primarily considered in the diagnosis because the patient presented with epileptic seizures and had lymphocytic pleocytosis in the CSF despite the OCB being pattern 3.
(1) all patients with idiopathic inflammatory demyelinating disease who fulfilled Wingerchuk criteria of 2006 for NMO excluding anti-AQP4 testing [2],
in 1971 from the brain of a patient with the initial JC, affected by Hodgkin's lymphoma who died of progressive multifocal leukoencephalopathy (PML), a demyelinating disease of the central nervous system (CNS) [2].
They describe ocular anatomy and eye examination, then core conditions in ophthalmology, including the ophthalmic features of systemic hypertension, diabetes, sarcoidosis, endocarditis, and demyelinating disease and space-occupying lesions of the brain, as well as how to recognize iritis, different forms of retinopathy, and the difference between papilloedema and papillitis.
Perhaps the most impactful role of DWI in the brain is in lesion characterization--the differentiation of stroke and abscess from tumor, and in the assessment and surveillance of demyelinating disease (Figure 1).
Since ON can herald a more diffuse demyelinating disease, care should be taken in making an accurate diagnosis, and careful consideration given to treatment options, particularly as other causes of ON not related to MS require quite different management.