Cerebrospinal fluid (CSF) protein, glucose, cell counts, and markers of acute demyelination
(oligoclonal banding, IgG indices) were normal; CSF polymerase chain reaction for herpes simplex virus and vaccinia virus were negative.
Neuroscience nurses need to develop a basic understanding of the proposed etiology of MS as well as of the process of demyelination
and the ionic basis of nerve conduction.
The neuronal loss and demyelination
in the present study account for the defective locomotor activity of the rats with spinal cord injuries.
Kluver-Barrera stain was used to demonstrate the presence of myelin sheaths of the axons in the white matter of the nervous tissue, as well as demyelination
. Histological analysis was performed with a compound light microscope, and photodocumentation was done using a Sony DSC-S930 SteadyShot 10.1 Megapixel digital camera.
Quantification of Demyelination
in the Optic Nerve.
MRI scan of the brain was performed which revealed bilateral symmetrical confluent areas of periventricular deep white matter signal change (demyelination
), in particular around the atria and frontal horns with sparing of subcortical U fibers (Figure-1)
Most patients note visual disturbances, secondary to optic nerve necrosis or demyelination
, as one of the first symptoms3.
Despite initial focus on white matter demyelination
, there has been increasing focus on the gray matter pathology occurring in MS.
Thus it is characterized by chronic demyelination
and axonal loss, inflammation, cell death and tissue damage (Versini et al., 2014; Ghaffari et al, 2015).
Electrophysiological tests were found to be abnormal and suggested a chronic, asymmetrical, sensory-motor axonal polyneuropathy with possible secondary demyelination
BioTime is now advancing three clinical stage product candidates for degenerative retinal diseases, neurological conditions associated with demyelination
, and aiding the body in detecting and combating cancer.
Changes observed on brain MRIs of patients treated with OTL-200 suggest that OTL-200 may prevent, stabilize or markedly delay the progressive atrophy and demyelination
typically observed with MLD.