dengue fever

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dengue fever

(dĕng`gē, –gā), acute infectious disease caused by four closely related viruses and transmitted by the bite of the female Aedes mosquito; it is also known as breakbone fever and bone-crusher disease. The disease occurs in both epidemic and sporadic form in warm climates (S United States, South America, the E Mediterranean countries, India, and especially SE Asia and the W Pacific). The classic symptoms, following an incubation period of five to eight days, are high fever, chills, severe headache, pain in the joints, pain behind the eyes, rash, sweating, and prostration, but infected persons may experience milder symptoms. Symptoms subside in two to four days, but after a remission lasting from a few hours to two days there is another rise in temperature, and a generalized rash appears. Convalescence is sometimes prolonged, with weakness and low blood pressure.

Dengue hemorrhagic fever, a severe form of the disease, can cause hemorrhage, shock, and encephalitis. It can occur when a person who has acquired immunity to one of the viruses that cause dengue fever is infected by a different dengue virus; antibodies to the first dengue infection apparently work to aid the second virus. It is a leading cause of death among children in Southeast Asia and in recent years has become increasingly prevalent in tropical America. There is no specific treatment for dengue fever except good nursing care. Both diseases can be controlled by eradicating the mosquitoes and destroying their breeding places. The mosquito population also has been controlled through the release of sterile male mosquitoes and the release of mosquitoes infected with bacteria that makes the insects incapable of transmitting viruses.

Dengue fever

[′deŋ·gē ‚fēv·ər]
(medicine)
An infection borne by the Aedes female mosquito, and caused by one of four closely related but antigenically distinct Dengue virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4). It starts abruptly after an incubation period of 2-7 days with high fever, severe headache, myalgia, and rash. It is found throughout the tropical and subtropical zones. Also known as break-bone fever.
References in periodicals archive ?
Dengue virus infection among children with undifferentiated fever in Karachi.
Keywords: Dengue virus, IgM capture ELISA, RT PCR, WHO criteria.
Therefore, serum IgM antibody testing for Zika and dengue virus infections should be performed if rRT-PCR is negative.
The scientists who made this discovery, a team of researchers from Australia, Vietnam and London, studied 145 dengue antibodies, which are natural agents developed by organisms that have the dengue virus in their cells (mosquitoes and humans).
It is crucial for a physician to diagnose dengue fever rapidly, properly, and accurately to achieve shorter operation time and to avoid excessive labor Diagnosis based on existing symptoms is very problematic since the initial dengue virus infection symptoms are similar to those of influenza, measles, malaria, typhus, yellow fever, and other virus infections [5].
M2 PHARMA-December 3, 2013-Visterra gets patent licence for monoclonal antibodies targeting Dengue virus
An Anti-Dengue Mixed Titer Performance Panel has recently been launched by SeraCare as its first commercially available line of infectious disease panels responding to the demand for accurate testing for dengue virus. It is designed to help blood donor collection facilities, diagnostics manufacturers, and clinical laboratories evaluate and troubleshoot their anti-dengue virus assays.
The serum samples were screened for the presence of dengue virus (DENV) specific IgM antibodies by MAC-ELISA kit supplied by the National Institute of Virology, Pune.
Institut Pasteur (Paris, France) and Centre National de la Recherche Scientifique (Paris, France) have patented viral vectors expressing different immunogens from the West Nile Encephalitis Virus (WNV) or the Dengue virus which are able to induce protective humoral and cellular immune responses against WNV or Dengue virus infections.
To the Editor: Dengue virus belongs to the genus Flavivirus, family Flaviviridae.