Thought to be developmental in origin, DC is caused by an anomaly in the reduced dental epithelium
Very weak immunoreactivity of [beta]-catenin in the dental epithelium
, as well as in surrounding mesenchyme.
The determination of tooth-forming sites during E10.5 [25-27] and the thickening of the dental epithelium at E11.5 have been considered as the first signs of tooth development .
FGFs are expressed in the dental epithelium throughout tooth development (Figure 1).
Localization of putative stem cells in dental epithelium
and their association witch notch and FGF signaling.
Bmp-2 Bmp-4 Bmp-7 shows expres- sion in dental epithelium
and have role in interaction with surrounding mesenchymal tissues.118 There is found no gender differences related to distribution of hypoplasia.
It has been shown that NT-4 regulates proliferation and differentiation of dental epithelium, and promotes the production of enamel matrixes (25).
It has been shown that NT-4 could regulate proliferation and differentiation of the dental epithelium and promote production of the enamel matrix (27).
Tooth development In utero, ectomesenchyme from the neural crest cells migrates to the site of tooth development and forms a complex signaling network with the dental epithelium
from the first branchial arch.
The dental epithelium
appears, and the horseshoe-shaped dental lamina generates the future dental arches at the late cap stage.