dephosphorylate


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dephosphorylate

[‚dē·fäs′fȯr·ə‚lāt]
(biochemistry)
To remove a phosphate group.
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References in periodicals archive ?
We speculate that the virion associated phosphatase VH1, which dephosphorylates STAT1 and STAT2 to block downstream IFN-[alpha] signalling [8, 9], may contribute, together with other VACV genes, to explaining this lack of IFN responses during VACV infection in the absence of B18 function.
IAP can dephosphorylate LPS on the outer membrane of gram-negative bacteria, thereby reducing its toxicity (Poelstra et al., 1997a,b; Koyama et al., 2002; Bates et al., 2007; Chen et al., 2011).
Upon phosphorylation, SHP2 is also activated, dissociates from the receptor and dephosphorylates the inhibitory tyrosine on c-Src C-terminus.
found that A[alpha] mutants can induce functional haploinsufficiency which can somehow lead to the deficiency to dephosphorylate Akt.
Several members can efficiently dephosphorylate p38[alpha] and p38[beta] (36-38); however, p38[gamma] and p38[delta] are resistant to all known MAPK phosphatase family members.
Protein phosphatases (PP1 and PP2B) were able to dephosphorylate the PKC[alpha] phosphorylated N-DAT; however, none of the tested protein phosphatases dephosphorylated the ERK1 phosphorylated N-DAT.
Once the peptide reaches a critical density in stationery growth ph ase, it is sensed by VncS, which acts as a phosphatase to dephosphorylate the response regulator, VncR.
The "on" state lasts as long as the phosphatase that can dephosphorylate the enzyme is not present.
Mitochondrial stress also generates reactive oxygen species (ROS) to activate the lysosomal [Ca.sup.2+] signalling and calcineurin to dephosphorylate TFEB and promote its nuclear translocation.
Two S1P-specific phosphatases, namely, S1P phosphatase-1 (SGPP1) and S1P phosphatase-2 (SGPP2), are located in the endoplasmic reticulum (ER) dephosphorylate S1P, regenerating sphingosine [37, 38].
MTMs dephosphorylate the position 3 of phosphatidylinositol phosphate (PIP) molecules PI(3)P and PI(3,5)[P.sub.2], making them important regulators of the endosomal compartment, the cytoskeleton, and ion channels [9].