Thus, PANDA depletion leads to senescence phenotypes by derepression
of p21 due to disruption of SAFA-PANDA-PRC interactions.
In this study, we determined that H19 competitively binds to miR-200a, suggesting that H19-mediated derepression
of [beta]-catenin is a potential mechanism by which this lncRNA promotes cell proliferation in CRC.
Over the past several years, increasing studies are focusing on the lncRNA-miRNA-mRNA regulatory mechanism that lncRNAs may serve as competing endogenous RNAs (ceRNAs), namely, miRNA sponges or antagomirs, to negatively regulate miRNAs, eventually resulting in the derepression
of miRNA targets .
Notably, when these regulatory lncRNAs are repressed the result can be a concomitant activation of their protein-coding counter parts expression as a result of derepression
of the lncRNA-targeted locus.
An analysis of the partial metabolic derepression
of sea urchin eggs by ammonia: the existence of independent pathways.
Stress leads to derepression
of specific genes whose functions are related to the stress.
Ghosh Choudhury, "Simvastatin induces derepression
of PTEN expression via NFkB to inhibit breast cancer cell growth," Cellular Signalling, vol.
[80.] Karu, T., "Derepression
of the Genome after irradiation of human lymphocytes with He-Ne laser," Laser Therapy, Vol.
The consequence of such derepression
would lead to reduction of Chop/CHOP and Atf3/ATF3 mRNA and protein expression.
of c-Fos caused by microRNA139 down-regulation contributes to the metastasis of human hepatocellular carcinoma.
(64) However, gene deprivation of EZH2 did not induce derepression
of HoxA9 expression unlike that of ASXL1 despite the fact that EZH2 and ASXL1 collaborate in repressing gene expression through EZH2-mediated H3K27me3.
acetivorans because this compound efficiently mediates in vivo derepression
of the artificial mcr[B.sub.P](tetO)/TetR system in this organism .