Systemic Treatment Efficacy for Onychomycosis (19) Patients Regimen Effective Cure Rate at 72 Weeks (a) Adults with dermatophyte
Intermittent terbinafine 79% (e) infection, great (n=63) (b) toenail, 20%-100% affected Continuous terbinafine 66% (e) (n=40) (c) Intermittent itraconazole 37% (e) (n=39) (d) (a) Simultaneous mycological cure and [less than or equal to] 10% nail involvement.
Onychomycosis is nail infection caused by keratolytic dermatophytes
(specifically, tinea unquium) (1) from the genera Trichophyton, Microsporum and Epider-mophyton, yeasts (mostly Candida (C.) albicans, C.
A study of chronic dermatophyte
infection in a rural hospital.
Depending on the dermatophyte
involved there can be risk of person-to-person transmission.
From this percentage, 90% corresponds to the toenails, being the main etiological agents the dermatophytes
such as: Trichophyton rubrum, yeasts of the genus Candida spp, presenting a higher prevalence in the nails of hands, and also we find non-dermatophytic molds, such as Fusarium spp, Aspergillus spp, Scopulariopsis spp and Acremonium spp, as responsible for 2% to 20% of the isolates in clinical samples of nails, being its interpretation as causal agent of the frequently complicated nail alteration.
Dermatophytid reactions occur in up to 5% of all dermatophyte
infections (most commonly tinea pedis) and are proposed to be type IV hypersensitivity reactions to the release of fungal antigens.
Considering high frequency of dermatophyte
infections around the world and possible vital role of amino acids with it, we performed this study.
Present study, however, targeted this lapse by validating differential diagnostic techniques between two dermatophyte
genera in a single reaction to reach exact diagnosis in time.
In another study by Machler et al routine histologic examination with PAS stain was found to be equal to culture and superior to KOH in leading to a diagnosis of dermatophyte
infection of nail5.
However, the extent to which non-dermatophyte molds actually cause dermatophytosis particularly when a dermatophyte
is present concurrently is still a subject of debate.
Observation of a dermatophyte
by SEM [5-9] reveals hyphae with clearly visible branches and septa or arthroconidia, whereas analysis of Candida in culture medium by SEM [10,11] often shows pseudohyphae, blastospores, budding, and a ring of bud scars.
More recently developed PCR techniques are considered to the new standard technique in detecting dermatophyte
presence  with detection rates similar to PAS staining technique .