7 In cutaneous mastocytosis, histamine release from their granules led to urticarial edema of the lesions, which results in secondary hyperpigmentation due to melanocytic activity at the dermoepidermal
The eczema-, psoriasis-, or dermatitis herpetiformis-like lesions on the extensor surfaces of the upper and lower limbs, especially, were confirmed histologically, but immunopathological evaluations revealed pervasive C3 deposits along the dermoepidermal
junction in a microgranular /granular pattern (82%).
EB has a wide variety of manifestations and complications, the major phenotypes have been described depending on the level of cleavage of the basement membrane at dermoepidermal
junction which are; simplex, junctional and dystrophic.
Direct immunofluorescence (DIF) demonstrated a strong linear deposition of IgG and less IgA and IgM, and also complements' (C3) deposition at the dermoepidermal
Authentic fibroblast matrix in dermal equivalents normalises epidermal histogenesis and dermoepidermal
junction in organotypic co-culture.
4,8,18) Originally extracted from the blister beetle but now synthesized commercially, (19) cantharidin causes vesiculation at the dermoepidermal
junction (6) by destroying intercellular connections.
These T-cells are increased in number at the dermoepidermal
junction of normal appearing skin; their aberrant activation leads to an inflammatory response, stimulating tissue destruction and formation of the classic fixed-drug lesion.
Another argument would be complement and immunoglobulin deposits at the dermoepidermal
junction with a lupus band-like appearance on direct immunofluorescence (6,8), the presence of lesions characterized by granulomatous inflammatory infiltrates, determined by epithelial debris, especially in advanced stage skin lesions.
Histologic features of primary syphilis involving the site of contact in the skin have been well characterized and include (1) a prominent bandlike inflammatory infiltrate, often rich in plasma cells and mixed with lymphocytes and histiocytes at the dermoepidermal
junction; (2) a dermal and perivascular chronic inflammatory infiltrate, often rich in plasma cells and mixed with lymphocytes and histiocytes; and (3) sometimes poorly formed granulomas.
skin analogs exhibit de novo formation of a near natural neurovascular link 10 weeks after transplantation.
They are so named because they are cell mediated immune reactions whose targets are basal keratinocytes that reside above the dermoepidermal
They comprised such characteristic features as lymphohistiocytic bandlike infiltrate occupying the upper dermis and obscuring the dermoepidermal
junction, irregular acanthosis resembling the typical saw-toothed appearance, extensive liquefactive degeneration of the basal layer of the epidermis with subepidermal clefts (Max Joseph spaces), pigmentary incontinence, and numerous cytoid bodies forming huge clusters.