While the use of noninsulated needle creates fractionalize damage to the epidermis, insulated needles only heat an area of the sphere at the tip of the needle, protecting the epidermis and the dermoepidermal
Benign melanocytic nevi (Figure 2, A) show a cobblestone pattern of epidermis and ring pattern, with edged papillae at the dermoepidermal
junction (Figure 2, B).
Thickness was measured from the surface of stratum corneum upto the dermoepidermal
Moreover, histopathological examination revealed dermoepidermal
separation in TEN and necrosis is present throughout the epidermis (1).
Her immunofluorescence showed linear deposits of C3 and IgG at dermoepidermal
junction along with subepidermal bullae containing fibrous exudates.
Histopathological examination revealed marked epidermotropic haloed lymphocytes linearly aligned along the basal layer with blurred dermoepidermal
junction and scant spongiosis (figure 2).
The aim was to inoculate the ANEM solution at dermoepidermal
junction, less response on the test sites could be due to inappropriate depth of the injection.
Histopathological examination revealed lentiginous hyperplasia, containing some small melanocytic nests at the dermoepidermal
showed, by comparing with the baseline, a reduction in the dermoepidermal
junction flattening with the reconstruction of the normal rete ridges and dermal papillae pattern in posttreatment samples .
Skin toxicity due to anti-PD-1 therapy is potentially mediated by a shared antigen coexpressed by the dermoepidermal
junction and tumour cells .
Clinically, fragile skin coverage manifests in blistering and may be caused by a delay in dermoepidermal
junction formation .
However, it has been proposed that the skin lesions seen in Schnitzler syndrome may be triggered by deposition of IgM in the epidermis and at the dermoepidermal