8) Interestingly, a recent study suggests that CD123-positive plasmacytoid dendrocytes are abundant at the dermoepidermal junction
in HLE, but they are present only as single or rare scattered clusters in squamous cell carcinoma and actinic keratoses.
In partial regression, melanocytes may be retained in nests and/or single cells at the dermoepidermal junction
Importantly, when a biopsy of a clinically typical lesion of LP shows equivocal histopathology, a positive lupus band test along the dermoepidermal junction
supports a diagnosis of LP.
However, many times, acral nevi do not form nests until they reach 2 or 3 mm in diameter, and the whole lesion will be a proliferation of single melanocytes along the dermoepidermal junction
The histopathologic recognition of early cutaneous melanoma is to a large extent based on the presence of an atypical lentiginous proliferation of melanocytes along the dermoepidermal junction