7 In cutaneous mastocytosis, histamine release from their granules led to urticarial edema of the lesions, which results in secondary hyperpigmentation due to melanocytic activity at the dermoepidermal junction
The eczema-, psoriasis-, or dermatitis herpetiformis-like lesions on the extensor surfaces of the upper and lower limbs, especially, were confirmed histologically, but immunopathological evaluations revealed pervasive C3 deposits along the dermoepidermal junction
in a microgranular /granular pattern (82%).
EB has a wide variety of manifestations and complications, the major phenotypes have been described depending on the level of cleavage of the basement membrane at dermoepidermal junction
which are; simplex, junctional and dystrophic.
4,8,18) Originally extracted from the blister beetle but now synthesized commercially, (19) cantharidin causes vesiculation at the dermoepidermal junction
(6) by destroying intercellular connections.
These T-cells are increased in number at the dermoepidermal junction
of normal appearing skin; their aberrant activation leads to an inflammatory response, stimulating tissue destruction and formation of the classic fixed-drug lesion.
They are so named because they are cell mediated immune reactions whose targets are basal keratinocytes that reside above the dermoepidermal junction
They comprised such characteristic features as lymphohistiocytic bandlike infiltrate occupying the upper dermis and obscuring the dermoepidermal junction
, irregular acanthosis resembling the typical saw-toothed appearance, extensive liquefactive degeneration of the basal layer of the epidermis with subepidermal clefts (Max Joseph spaces), pigmentary incontinence, and numerous cytoid bodies forming huge clusters.
8) Interestingly, a recent study suggests that CD123-positive plasmacytoid dendrocytes are abundant at the dermoepidermal junction
in HLE, but they are present only as single or rare scattered clusters in squamous cell carcinoma and actinic keratoses.
The direct immunofluorescence examination of skin biopsy obtained from her arm showed immunoglobulin deposition at dermoepidermal junction
which was thought to be consistent with pathologic finding of systemic lupus erythematosus.
The biopsy revealed a mild superficial perivascular lymphohistiocytic infiltrate, scattered melanophages in the papillary dermis and focal areas with smudging of the dermoepidermal junction
In partial regression, melanocytes may be retained in nests and/or single cells at the dermoepidermal junction
Confocal microscopy shows the dermoepidermal junction
healing as early as within 2 days.