Two cases who showed infiltrative invasion and architectural complexity with desmoplasia
were diagnosed with well-differentiated mucinous adenocarcinoma (Figure 8-10).
TGF-[beta] has been related to tumor aggressiveness and invasiveness and to the activation of PSCs, leading to pancreatic desmoplasia
. TGF-[beta] is also associated to immune cell regulation, migration, and proliferation .
For example, breast cancer is neighbored by adipose tissue; pancreatic cancer is accompanied by massive desmoplasia
. Given that the same cytokine can result in opposite biological effects in different types of cancer, that is, tumor promoting versus tumor inhibiting due to their unique tumor environment, it is important to comprehensively review cytokine signaling and its functions during cancer development in each type of cancer for shedding light on cancer therapies by altering the tumor environment.
Some areas showed solid tumor nests (Figure 2(a)), while another showed linear and single cell infiltration with prominent desmoplasia
Pancreatic cancer is characterized by remarkable desmoplasia
creates an auspicious microenvironment for tumor proliferation by originating a hypoxic and acidic niche as well as generating a mechanical stretch that is responsible for converting fibroblast to myofibroblast that also contributes to cancer heterogeneity and drug resistance .
Minervini et al., "Desmoplasia
influenced recurrence of disease and mortality in stage III colorectal cancer within five years after surgery and adjuvant therapy," Saudi Journal of Gastroenterology, vol.
(B) Mechanisms explaining the tumour microenvironment role in immunoediting are best illustrated in studies on human and mouse pancreatic cancer models, since desmoplasia
is the pathologic hallmark of pancreatic cancer [23, 24].
Microscopically, the tumours showed diffuse infiltration by signet ring cells with surrounding zones of desmoplasia
The tumor showed foci of squamous metaplasia (blue arrow) infiltrating the soft tissues and areas of dense hyalinization with focal desmoplasia
of the connective tissue (yellow arrow), suggestive of an ameloblastoma with mixed subtypes consisting of follicular, cystic, acanthomatous, and desmoplastic variants (figures 4A, B, and C).
Fueron reportadas 33 mitosis en 10 hpf (high power fields), invasion estromal y vascular individual y embolica, desmoplasia
, cambio circulatorio e inflamatorio asociado.
The intervening stroma showed desmoplasia
and lymphocytic infiltrates.