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see skin cancerskin cancer,
malignant tumor of the skin. The most common types of skin cancer are basal cell carcinoma, squamous cell carcinoma, and melanoma. Rarer forms include mycosis fungoides (a type of lymphoma) and Kaposi's sarcoma.
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melanoblastoma; a malignant tumor that consists of melanin-producing cells.

Factors conducive to the development of melanomas include injury and hormonal stimulation, especially during puberty. Melanomas generally occur on the skin; less often, they appear on the retina, pia mater, nasopharynx, larynx, esophagus, and mucosa of the intestine and other organs. Melanomas usually develop at the site of pigmented or depigmented birthmarks, but they may also appear elsewhere. The process starts with a barely perceptible, painless tumor on the skin, sometimes resembling a wart, which gradually becomes dark brown or black. Occasionally, it ulcerates and bleeds. In case of injury, the tumor may enlarge quickly and become tuberous, dense at the base, and stiffer. The regional lymph nodes enlarge. The initial signs that a melanoma is developing at the site of a birthmark are the birthmark’s enlargement, an intensification or reduction in its pigmentation, and the appearance of a red rim around it. Treatment involves prompt surgical intervention, based on early diagnosis, and the use of radiotherapy and drugs to retard the growth and reproduction of the cells.



A malignant tumor composed of anaplastic melanocytes.
A benign or malignant tumor composed of melanocytes.


Pathol a malignant tumour composed of melanocytes, occurring esp in the skin, often as a result of excessive exposure to sunlight
References in periodicals archive ?
Therefore, patients with advanced desmoplastic melanoma derive substantial clinical benefit from PD-1 or PD-L1 immune checkpoint blockade therapy, even though desmoplastic melanoma is defined by its dense desmoplastic fibrous stroma.
3-8,16) Historically, three main subtypes of melanoma including superficial spreading melanoma (SSM), lentigo maligna melanoma (LMM) and nodular melanoma (NM) were first described in 1969; (9) desmoplastic melanoma (DM) was added in 1971; (12) and acral lentiginous melanoma (ALM) was introduced in 197710 and defined in 1980.
Two of the less common subtypes of malignant melanoma are desmoplastic melanoma and conventional melanoma arising in mucosa.
CD10, p63 and CD99 expression in the differential diagnosis of atypical fibroxanthoma, spindle cell squamous cell carcinoma and desmoplastic melanoma.
Desmoplastic melanoma is often amelanotic and often consists of a proliferation of only mildly atypical spindle cells in a fibrotic collagenous stroma, which typically invade deeply, reminiscent of a scar or a nonmelanocytic spindle cell neoplasm (Figure 13, B), thus occasionally leading to a wrong diagnosis.
21) Consistently, FISH results are abnormal in almost all metastatic melanomas and aggressive nodular melanomas and in only 50% of more-indolent desmoplastic melanoma.
Assessment of the role of sentinel lymph node biopsy for primary cutaneous desmoplastic melanoma.
Another marker that may be helpful in distinguishing desmoplastic nevus from desmoplastic melanoma is MART1.
23,29) Sclerosing (Desmoplastic) Blue Nevus Sclerosing BN, also known as a desmoplastic blue nevus, is an important morphologic variant of BN, which must not be confused with desmoplastic melanoma or a soft tissue tumor.
A tumor subgroup that may not benefit from the examination of SLN is that of pure desmoplastic melanoma, since such lesions only rarely metastasize to the SLN.
32 Because MUM1 expression appears to be present in both nevi and in melanomas, and it does not highlight desmoplastic melanoma more effectively than well-established stains do, it is unclear whether it will have a role in the future and what that role would be.