desmosome

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desmosome

[′dez·mə‚sōm]
(cell and molecular biology)
References in periodicals archive ?
Human autoantibodies against a desmosomal core protein in pemphigus foliaceus.
13) Breakthroughs in this setting informed the field that dysfunctional desmosomes may be the root of the disease and led to the discovery of many desmosomal genes implicated in AC (Table 2).
1) Desmosomal proteins link epithelial cells to each other.
Perp deficiency caused defects in desmosomal protein expression in breast epithelial cells," Dr Attardi said.
Additionally, expression of several gene transcripts such as heat shock protein 70 (Hsp70), interferon tau (IF-tau), DNA methyl-transferase 3a (Dnmt3a), desmosomal glycoprotein desmocollin III (DcIII) and insulin-like growth factor II receptor (Igf-2r) were altered in accordance to different culture conditions (6).
Desmosomal proteins: new markers for identification and classification of tumors.
The plakoglobin, desmoplakin and desmocollin-2 are family members of desmosomal proteins that function as cell-cell adhesion junction, and are expressed in skin, heart and hair.
Ultrastructural studies show that E-cadherin on the cytoplasmic membrane of the keratinocytes is shifted to desmosomes under physiological conditions and therein expresses an adhesion function in association with other desmosomal cadherins.
Desmogleins are calcium-binding transmembrane glycoproteins, members of the desmosomal cadherins that provide adhesive integrity to desmosomes between adjoining keratinocytes; They consist of proteins Dsg1, Dsg2, Dsg3, and Dsg4.
Though the pathogenic mechanism in ARVD/C is not completely understood, it is believed that defects in desmosomal components, which provide mechanical coupling between the intermediate filaments and the cytoplasmic membranes of adjacent cells, may compromise its adhesive function, predisposing to myocyte detachment and death.
Se caracteriza por la presencia de ampollas superficiales subcorneales y autoanticuerpos de tipo Ig G que son especificos para la region extracelular de la glicoproteina desmosomal desmogleina 1, encargada de la union entre celulas epidermicas.