desmosome


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desmosome

[′dez·mə‚sōm]
(cell and molecular biology)
References in periodicals archive ?
These junctions comprise cell-to-cell adhesion junctions composed of fascia adherens, gap junctions, and maculae adherentes (desmosomes).
Results are expressed as means [+ or -] SEM of desmosome protein (desm) and TUNEL-positive cells per area ([mm.sup.2]) (n = 7).
Nearly 50% of patients suffering from ARVD have mutations in genes which encode desmosomes components--desmoplakin, plakoglobin, plakophilin-2, desmoglein-2, and desmocollin-2 [53].
TEHRAN (FNA)- Scientists at the University of Manchester have made an important discovery about how cells in the skin and heart are bound together through structures called desmosomes.
Under the zonula occludens and forming an axis in an apical-basal direction are three types of adherence junctions: zonula adherens, also known as belt desmosomes; macula adherens, or punctate desmosomes; and hemidesmosomes.
Thomason et al., "p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome," Human Molecular Genetics, vol.
Mutations at the inner dense plaque, particularly affecting the desmin-binding site of desmoplakin may result in ARVD/C with predominantly left ventricular involvement and clinical overlapping with dilated cardiomyopathy, while the mutations affecting the outer dense plaque of desmosome (desmoglein2, plakoglobin, plakophilin2 and the N-terminal of desmoplakin) result in ARVD/C with the ordinary described phenotype indicating that mutations in the same gene at different locations might lead to different phenotypes either ARVD/C or ALVC (50).
ARVC is a disease of the desmosome, so skin manifestations--including palmar keratosis--are a clue that it may be present.
SLUG is a member of the Snail family of transcription factors that acts to suppress ECAD expression and helps regulate tight and adherent junction stability, desmosome disassembly, and protease expression (8).