desmosome


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desmosome

[′dez·mə‚sōm]
(cell and molecular biology)
References in periodicals archive ?
5) These symptoms depend on the sites of impaired desmosome function and usually vary in their presentation, such as oral pain, stinging, sore throat, hoarseness, dysphonia, dysphagia, odynophagia, epistaxis, nasal congestion, blood-tinged mucus, otalgia, ear canal obstruction, vaginal discharge and pain, ocular pain, and excessive tearing.
Nearly 50% of patients suffering from ARVD have mutations in genes which encode desmosomes components--desmoplakin, plakoglobin, plakophilin-2, desmoglein-2, and desmocollin-2 [53].
Lechaire, "Calcium-modulated desmosome formation and sodium-regulated keratinization in frog skin cultures," Tissue and Cell, vol.
He says there are exciting implications for these findings, "This is the first time that any structural information has been reported for desmosome adhesion.
We know that people who have defects in their desmosomes have problems with their epidermis and get extremely unpleasant skin diseases.
Desmosome antagonists should be useful in breaking down tissue and tumor barriers to facilitate drug delivery to the tumor.
Electron microscopy reveals loss of desmosomes, breakdown of desmosome-keratin intermediate filament attachment, and perinuclear aggregates of keratin intermediate filaments.
As the sequence of peptide contained in Cellcon is derived from desmoglein-1, the higher amount of this sequence in a cell simulates desmosome degradation.
Electron microscopy reveals loss of desmosomes (epithelial intercellular junctions formed by membrane and submembrane protein complexes), breakdown of desmosome-keratin intermediate filament attachment, and perinuclear aggregates of keratin intermediate filaments.
Once again, the alternative adhesion junction complexes that have been implicated in later stages of cancer appeared to be present and functioning normally in almost all of these samples, further supporting the idea that desmosome loss due to Perp inactivation can be an early, defining event in cancer progression.
Shared desmosome gene findings in early and late onset arrhythmogenic right ventricular dysplasia/cardiomyopathy.